30 Recruiting Sickle Cell Disease Phase 1 Clinical Trials
Active phase 1 studies for sickle cell disease enrolling across the USA. Verify eligibility and contact site coordinators.
All Sickle Cell Disease studiesPhase 1 Studies for Sickle Cell Disease
BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
📍 University of Alabama at Birmingham — Birmingham, Alabama
View Study & Checklist ➔Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔Long-term Follow-up (LTFU) of Patients Treated With Genome-edited Autologous Hematopoietic Stem and Progenitor Cells (HSPC)
📍 University of Chicago — Chicago, Illinois
View Study & Checklist ➔Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY)
📍 UCSF Benioff Children's Hospital — Oakland, California
View Study & Checklist ➔TMLI and Alemtuzumab for Treatment of Sickle Cell Disease
📍 City of Hope Medical Center — Duarte, California
View Study & Checklist ➔A Blood Stem Cell Transplant for Sickle Cell Disease
📍 City of Hope Medical Center — Duarte, California
View Study & Checklist ➔Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ Function
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD)
📍 University of Illinois at Chicago — Chicago, Illinois
View Study & Checklist ➔Safety of Blood Stem Cell Mobilization With Plerixafor in Patients With Sickle Cell Disease
📍 City of Hope Medical Center — Duarte, California
View Study & Checklist ➔Gene Transfer for Sickle Cell Disease
📍 UCLA - Mattel Children's Hospital — Los Angeles, California
View Study & Checklist ➔Feasibility and Acceptability of Amani
📍 Massachusetts General Hospital — Boston, Massachusetts
View Study & Checklist ➔Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Sickle Cell Disease
📍 Boston Children's Hospital — Boston, Massachusetts
View Study & Checklist ➔Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease
📍 City of Hope Medical Center — Duarte, California
View Study & Checklist ➔Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
📍 Children's Hospital Los Angeles — Los Angeles, California
View Study & Checklist ➔Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
📍 University of Alabama Birmingham — Birmingham, Alabama
View Study & Checklist ➔Cannabidiol in Sickle Cell Disease
📍 Icahn School of Medicine at Mount Sinai — Manhattan, New York
View Study & Checklist ➔Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies
📍 Boston Children's Hospital — Boston, Massachusetts
View Study & Checklist ➔Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease
📍 Augusta University — Augusta, Georgia
View Study & Checklist ➔A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
📍 University of Illinois at Chicago College of Medicine — Chicago, Illinois
View Study & Checklist ➔Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease
📍 University of California, Los Angeles — Los Angeles, California
View Study & Checklist ➔SCD Stem Cell Mobilization and Apheresis Using Motixafortide
📍 University of Alabama at Birmingham — Birmingham, Alabama
View Study & Checklist ➔A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
📍 University of Alabama at Birmingham — Birmingham, Alabama
View Study & Checklist ➔Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
📍 Children's Hospital of Colorado — Aurora, Colorado
View Study & Checklist ➔Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔Gene Editing For Sickle Cell Disease
📍 St. Jude Children's Research Hospital — Memphis, Tennessee
View Study & Checklist ➔Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease
📍 Children's Healthcare fo Atlanta at Hughes Spalding — Atlanta, Georgia
View Study & Checklist ➔Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
📍 St. Jude Children's Research Hospital — Memphis, Tennessee
View Study & Checklist ➔