42 Recruiting Sickle Cell Disease Phase 2 Clinical Trials
Active phase 2 studies for sickle cell disease enrolling across the USA. Verify eligibility and contact site coordinators.
All Sickle Cell Disease studiesPhase 2 Studies for Sickle Cell Disease
BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
📍 University of Alabama at Birmingham — Birmingham, Alabama
View Study & Checklist ➔Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔Haplo T-Cell Depleted Transplantation in High-Risk Sickle Cell Disease
📍 University of California Los Angeles (UCLA) — Los Angeles, California
View Study & Checklist ➔A Study Evaluating the Safety and Efficacy of EDIT-301 in Participants With Severe Sickle Cell Disease (RUBY)
📍 UCSF Benioff Children's Hospital — Oakland, California
View Study & Checklist ➔A Dose-Finding Study of Tebapivat to Assess Efficacy, and Safety in Participants With Sickle Cell Disease (SCD)
📍 UConn Health — Farmington, Connecticut
View Study & Checklist ➔A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)
📍 University of California San Diego — La Jolla, California
View Study & Checklist ➔Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation
📍 Children's Hospital of Alabama — Birmingham, Alabama
View Study & Checklist ➔Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔Non-myeloablative Haploidentical HCT Study for Patients With Sickle Cell Disease, Including Compromised Organ Function
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001)
📍 Children's Hospital of Los Angeles — Los Angeles, California
View Study & Checklist ➔Ph I/II Study of Allogeneic SCT for Clinically Aggressive Sickle Cell Disease (SCD)
📍 University of Illinois at Chicago — Chicago, Illinois
View Study & Checklist ➔An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemia
📍 University of Connecticut Health Center — Farmington, Connecticut
View Study & Checklist ➔Assessing Physical Function in Sickle Cell Patients Taking Voxelotor
📍 Inova Schar Cancer Institute — Falls Church, Virginia
View Study & Checklist ➔Feasibility and Acceptability of Amani
📍 Massachusetts General Hospital — Boston, Massachusetts
View Study & Checklist ➔Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor
📍 Alberta Children's Hospital — Calgary, Alberta
View Study & Checklist ➔Intravenous L-Citrulline for Vaso-occlusive Pain Episode in Sickle Cell Disease
📍 Children's National Hospital — Washington D.C., District of Columbia
View Study & Checklist ➔Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell Antibody
📍 Children's National Hospital — Washington D.C., District of Columbia
View Study & Checklist ➔Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease
📍 University of Illinois at Chicago — Chicago, Illinois
View Study & Checklist ➔Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
📍 Children's Hospital Los Angeles — Los Angeles, California
View Study & Checklist ➔Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial
📍 UCSF Benioff Children's Hospital Oakland — Oakland, California
View Study & Checklist ➔A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
📍 University of Alabama Birmingham — Birmingham, Alabama
View Study & Checklist ➔Cannabidiol in Sickle Cell Disease
📍 Icahn School of Medicine at Mount Sinai — Manhattan, New York
View Study & Checklist ➔Alendronate for Osteonecrosis in Adults With Sickle Cell Disease
📍 UC Davis Comprehensive Cancer Center — Sacramento, California
View Study & Checklist ➔A Study to Evaluate the Pharmacokinetics and Safety of Etavopivat in Pediatric Patients With Sickle Cell Disease
📍 The Hospital for Sick Children — Toronto, Ontario
View Study & Checklist ➔Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)
📍 UAMS Medical Center — Little Rock, Arkansas
View Study & Checklist ➔Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors
📍 National Institutes of Health Clinical Center — Bethesda, Maryland
View Study & Checklist ➔Tocilizumab for Acute Chest Syndrome
📍 University of Chicago — Chicago, Illinois
View Study & Checklist ➔Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults
📍 Harbor UCLA Medical Center — Torrance, California
View Study & Checklist ➔Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease
📍 University of California, Los Angeles — Los Angeles, California
View Study & Checklist ➔Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell Disease
📍 St Jude Children's Research Hospital — Memphis, Tennessee
View Study & Checklist ➔Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain
📍 Mount Sinai Hospital — New York, New York
View Study & Checklist ➔A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)
📍 Memorial Sloan Kettering at Basking Ridge (Consent only) — Basking Ridge, New Jersey
View Study & Checklist ➔Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
📍 Children's Hospital of Colorado — Aurora, Colorado
View Study & Checklist ➔Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease
📍 University of California Los Angeles — Los Angeles, California
View Study & Checklist ➔Cognitive Remediation Intervention to Prepare for Transition of Care
📍 University of Alabama at Birmingham — Birmingham, Alabama
View Study & Checklist ➔Arginine Therapy for the Treatment of Pain in Children With Sickle Cell Disease
📍 Children's Healthcare fo Atlanta at Hughes Spalding — Atlanta, Georgia
View Study & Checklist ➔A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
📍 AMR Clinical — Mobile, Alabama
View Study & Checklist ➔Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
📍 Children's National Health System — Washington D.C., District of Columbia
View Study & Checklist ➔Efficacy and Safety of SIL-8301 for Control of Hemolysis in a Uniform Sickle Cell Disease Endotype
📍 The Hospital for Sick Children — Toronto, Ontario
View Study & Checklist ➔Early Screening and Treatment of Heart Complication in Sickle Cell Disease
📍 Inova Schar Cancer — Fairfax, Virginia
View Study & Checklist ➔Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
📍 St. Jude Children's Research Hospital — Memphis, Tennessee
View Study & Checklist ➔