26 Paid Clinical Research Studies in Durham, North Carolina
Filtered for protocols that accept healthy volunteers or mention compensation. Always confirm stipend details and screening with the study coordinator.
Botensilimab and Balstilimab Optimization in Colorectal Cancer
This is a single-arm, interventional, pilot clinical trial. Fifteen evaluable patients will have tumor-informed ctDNA testing at baseline and start botensilimab and balstilimab tre
📍 Duke University — Durham, North Carolina
View Study & Checklist ➔Multisite Prevention of Conduct Problems (Fast Track)
The primary aim of this project is to evaluate the effects of a comprehensive intervention to prevent severe and chronic conduct problems in a sample of children selected as high-r
📍 Duke University — Durham, North Carolina
View Study & Checklist ➔Pancoronavirus Vaccine Study in Healthy Adults
Coronaviruses (CoVs) have caused the severe acute respiratory syndrome (SARS) outbreak, the Middle East Respiratory Syndrome (MERS) outbreak, and now the severe acute respiratory s
📍 Duke University Health System — Durham, North Carolina
View Study & Checklist ➔DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab
Patients with newly diagnosed glioblastoma will be consented following tumor resection then undergo leukapheresis for harvest of peripheral blood leukocytes for generation of dendr
📍 Duke University Medical Center — Durham, North Carolina
View Study & Checklist ➔ETAPA I: Peptide-based Tumor Associated Antigen Vaccine in GBM
This is a phase 1b study of P30-linked EphA2, CMV pp65, and survivin vaccination (collectively called the P30-EPS vaccine) in HLA-A\*0201 positive patients with a newly diagnosed,
📍 The Preston Robert Tisch Brain Tumor Center at Duke University — Durham, North Carolina
View Study & Checklist ➔Gulf War Era Cohort and Biorepository
The Gulf War Era Cohort and Biorepository pilot project collected epidemiological, survey, clinical, and environmental exposure data from Veterans who served during the 1990-1991 G
📍 Durham VA Medical Center, Durham, NC — Durham, North Carolina
View Study & Checklist ➔Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab
Subjects with resectable melanoma will receive neoadjuvant nivolumab followed by surgical resection. Post-operatively, subjects will receive open-label treatment with up to 1 year
📍 Duke Cancer Institute — Durham, North Carolina
View Study & Checklist ➔Hepatic Artery Chemotherapy for Patients With Localized Pancreas Cancer
This is a window-of-opportunity study which will evaluate the safety and feasibility of single-dose neoadjuvant Hepatic Artery (HA) chemotherapy (FUDR/oxaliplatin) in patients with
📍 Duke University Health System — Durham, North Carolina
View Study & Checklist ➔PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma
The primary goal of this prospective clinical trial is to evaluate the safety of PEP-CMV in patients with recurrent medulloblastoma and malignant glioma. Patients with histological
📍 Duke University Medical Center — Durham, North Carolina
View Study & Checklist ➔Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study
A parallel-group randomized pilot trial at a single institution (Duke University) on the effect of postoperative hyperbaric oxygen therapy on wound healing in patients with soft ti
📍 Duke University — Durham, North Carolina
View Study & Checklist ➔Baby Steps III: Testing a Clinician and Patient Intervention to Promote Smoking Cessation Among Pregnant Women
The investigators propose to conduct a combined intervention that pairs SMS smoking cessation messages for patients with individualized training for OB clinicians to improve quit r
📍 Durham OB — Durham, North Carolina
View Study & Checklist ➔Spinal Cord Stimulation (SCS) for Spinal Cord Injury (SCI)
The purpose of this feasibility study is to compare the impact of Spinal cord stimulation \[SCS\] for Spinal Cord Injury (SCI) pain and rehabilitation. SCS, also known as Epidural
📍 Duke University Health Systems — Durham, North Carolina
View Study & Checklist ➔Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations
This study will evaluate the safety and efficacy of a recombinant adeno-associated virus vector (rAAV2tYF-GRK1-RPGR) in patients with X-linked retinitis pigmentosa caused by RPGR m
📍 Duke University — Durham, North Carolina
View Study & Checklist ➔Shared Decision Making to Address Racial Disparities in Oral Anticoagulation in NVAF
The study is a pilot analysis using a decision on the risk and benefits of oral anticoagulation for stroke reduction for patients with non-valvular atrial fibrillation. This study
📍 Duke University Medical Center — Durham, North Carolina
View Study & Checklist ➔Leveraging Interactive Digital Technology to Increase Access to Family-Based Behavioral Treatment for Childhood Obesity
The primary goal of this SBIR Direct to Phase II is to expand upon the existing training platform to create an "all-in-one" digital product, FBT 2.0, that offers an integrated suit
📍 3C Institute — Durham, North Carolina
View Study & Checklist ➔Using Community Health Workers to Support Rural Care Partners of Seriously Ill Older Veterans
The investigators aim to support care partner's well-being and satisfaction with VA care and decrease their work burden by offering extra support from a trained Community Health Wo
📍 Durham VA Medical Center, Durham, NC — Durham, North Carolina
View Study & Checklist ➔Studies of Insulin and Glucagon Action in the Liver
This study examines how glucagon works to regulate glucose metabolism, based on new findings that suggest glucagon signaling in the liver has more than one role, and that these mul
📍 Duke Center for Living — Durham, North Carolina
View Study & Checklist ➔Food DNA Digestion
This pilot study investigates the digestion rate of naturally occurring food DNA through the human digestive tract by detecting residual food DNA in stool samples. The investigator
📍 Medical Sciences Research Building III (MSRB III) — Durham, North Carolina
View Study & Checklist ➔Mitigating Racial Disparities in Shared Decision Making in the Intensive Care Unit
This is a non randomized pilot trial aimed to: Test the feasibility of an intervention to support intensive care unit clinicians in conducting shared decision making conversations
📍 Duke University Medical Center — Durham, North Carolina
View Study & Checklist ➔Ultrasound Imaging of the Head, Neck, and Airway
Purpose and Objectives: The main purpose is to test an ultrasound device that can assess the upper airway to create dynamic 4D imaging, which current technology cannot do. Ultrasou
📍 Duke Hospital — Durham, North Carolina
View Study & Checklist ➔SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers
The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in
📍 Duke University Medical Center — Durham, North Carolina
View Study & Checklist ➔NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings
The investigators plan to conduct an R61/33 hybrid type 2 implementation-effectiveness trial that includes 1) a one-year exploratory R61 phase that will enable the development of t
📍 Duke University Medical System — Durham, North Carolina
View Study & Checklist ➔Lung Cancer and Aging: Improving Well-being for Older Adults With Lung Cancer
The purpose of this study is to develop a brief assessment and need-based behavioral intervention for addressing aging-specific concerns in older adults with lung cancer. The long-
📍 Duke University Health System — Durham, North Carolina
View Study & Checklist ➔Compact Auto-Aligning Multi-Modal Eye Imaging to Diagnose Traumatic Eye Injury
The purpose of this study is to test an investigational eye imaging device by taking pictures of participants eyes with a single image capture that takes only seconds.
📍 Duke Eye Center — Durham, North Carolina
View Study & Checklist ➔Boosting Exercise Adherence in Knee Osteoarthritis
This project, conducted within the Department of Veterans Affairs Healthcare System (VHA), will test the effectiveness of an intervention to improve adherence to home exercise amon
📍 Durham VA Medical Center, Durham, NC — Durham, North Carolina
View Study & Checklist ➔BMX-001 + Paclitaxel in Adult Patients With Advanced, Recurrent, Metastatic Ovarian or Endometrial Cancer
This research project addresses the urgent need for novel therapeutic strategies to overcome chemotherapy resistance and mitigate chemotherapy-induced peripheral neuropathy (CIPN)
📍 Duke Cancer Institute — Durham, North Carolina
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