Lenalidomide and Dexamethasone With or Without Thalidomide in Treating Patients With Multiple Myeloma (NCT00098475)
A Randomized Phase III Study of CC-5013 Plus Dexamethasone Versus CC-5013 Plus Low Dose Dexamethasone in Multiple Myeloma With Thalidomide Plus Dexamethasone Salvage Therapy for Non-Responders
🩺 Plain-English Summary (8th-Grade Level)
This randomized phase III trial studies lenalidomide and low-dose dexamethasone to see how well it works compared to lenalidomide and standard-dose dexamethasone, given with or without thalidomide, in treating patients with multiple myeloma. Biological therapies, such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing. Lenalidomide and thalidomide may also stop the growth of multiple myeloma by blocking blood flow to the cancer. Drugs used in chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving lenalidomide, thalidomide, and dexamethasone together may kill more cancer cells.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (138 Sites)
Showing the first 25 of 138 sites.
- University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
- Huntsville Hospital — Huntsville, Alabama
- Providence Alaska Medical Center — Anchorage, Alaska
- Mayo Clinic in Arizona — Scottsdale, Arizona
- Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California
- Saint Jude Medical Center — Fullerton, California
- El Camino Hospital — Mountain View, California
- Kaiser Permanente-Rio San Diego — San Diego, California
- The Medical Center of Aurora — Aurora, Colorado
- Penrose-Saint Francis Healthcare — Colorado Springs, Colorado
- Saint Joseph Hospital - Cancer Centers of Colorado — Denver, Colorado
- Swedish Medical Center — Englewood, Colorado
- Poudre Valley Hospital — Fort Collins, Colorado
- Banner North Colorado Medical Center - Loveland Campus — Loveland, Colorado
- Danbury Hospital — Danbury, Connecticut
- Eastern Connecticut Hematology and Oncology Associates — Norwich, Connecticut
- Holy Cross Hospital — Fort Lauderdale, Florida
- UF Health Cancer Institute - Gainesville — Gainesville, Florida
- Baptist MD Anderson Cancer Center — Jacksonville, Florida
- Mayo Clinic in Florida — Jacksonville, Florida
- Martin Hospital South — Stuart, Florida
- Phoebe Putney Memorial Hospital — Albany, Georgia
- Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia
- Atlanta Regional CCOP — Atlanta, Georgia
- Augusta Oncology Associates PC-D'Antignac — Augusta, Georgia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.