🏛️ Verified NIH Record • Updated 2025-10-03
Treatment of Orthostatic Intolerance (NCT00262470)
🔵 Active, Not Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: Satish R. Raj
🩺 Plain-English Summary (8th-Grade Level)
This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with this disorder.
Who can join: Review the eligibility criteria below.
Location: Vanderbilt University Autonomic Dysfunction Center — Nashville, Tennessee
Age range: 18 Years to 70 Years
🧪 Interventions in This Study
- Acetazolamide (DRUG)
- Atomoxetine (DRUG)
- Clonidine (DRUG)
- Entacapone (DRUG)
- Entacapone & Propranolol (DRUG)
- Atomoxetine & Propranolol (DRUG)
- Indomethacin (DRUG)
- Mecamylamine (DRUG)
- Isosorbide Dinitrate (DRUG)
- Melatonin (DIETARY_SUPPLEMENT)
- Midodrine (DRUG)
- Modafinil (DRUG)
- Octreotide (DRUG)
- Propranolol (DRUG)
- Modafinil & Propranolol (DRUG)
- Sertraline (DRUG)
- Breathing Device (DEVICE)
- memantine (DRUG)
- Abdominal binder (DEVICE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Vanderbilt University Autonomic Dysfunction Center — Nashville, Tennessee
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Tachycardia
- Pathophysiology of Orthostatic Intolerance — Nashville, Tennessee
Explore by condition: All Tachycardia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.