Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas (NCT00268385)
A Phase I Study of Vorinostat (Suberoylanilide Hydroxamic Acid [SAHA]) in Combination With Temozolomide in Patients With Malignant Gliomas
🩺 Plain-English Summary (8th-Grade Level)
This phase I trial is studying the side effects and best dose of vorinostat when given together with temozolomide in treating patients with malignant gliomas. Drugs used in chemotherapy, such as vorinostat and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Vorinostat may also stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Vorinostat may help temozolomide work better by making tumor cells more sensitive to the drug. Giving vorinostat together with temozolomide may kill more tumor cells.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (17 Sites)
- University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
- UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California
- UCSF Medical Center-Mount Zion — San Francisco, California
- Moffitt Cancer Center — Tampa, Florida
- Emory University Hospital/Winship Cancer Institute — Atlanta, Georgia
- Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore, Maryland
- National Cancer Institute Neuro-Oncology Branch — Bethesda, Maryland
- Dana-Farber Cancer Institute — Boston, Massachusetts
- Henry Ford Hospital — Detroit, Michigan
- Memorial Sloan Kettering Cancer Center — New York, New York
- Duke University Medical Center — Durham, North Carolina
- Wake Forest University Health Sciences — Winston-Salem, North Carolina
- Cleveland Clinic Foundation — Cleveland, Ohio
- University of Pennsylvania/Abramson Cancer Center — Philadelphia, Pennsylvania
- UPMC Hillman Cancer Center — Pittsburgh, Pennsylvania
- UT MD Anderson Cancer Center — Houston, Texas
- University of Wisconsin Carbone Cancer Center - University Hospital — Madison, Wisconsin
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Adult Anaplastic Astrocytoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.