Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma (NCT00288119)
Genetic and Environmental Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma
🩺 Plain-English Summary (8th-Grade Level)
The overall objectives of this BETRNet Research Center (RC) are: 1. to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (ECA) 2. to increase the biological understanding of key observations made by our clinical researchers; 3. to translate knowledge derived from genetic, epigenetic, and transcriptome research to solving clinical dilemmas in detection, prognosis, prevention, and therapy of BE in order to prevent EAC and improve the outcomes of EAC; 4. to foster a transdisciplinary and translation research culture and to effectively expand and enhance scientific research focused on BE and EAC; 5. to evaluate research and transdisciplinary programs and to continuously improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this RC proposal is 1) to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; and 2) to then translate laboratorydiscoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.
Who can join: Review the eligibility criteria below.
Location: Johns Hopkins Hospital — Baltimore, Maryland
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (10 Sites)
- Johns Hopkins Hospital — Baltimore, Maryland
- Mayo Clinic — Rochester, Minnesota
- Washington University School of Medicine — St Louis, Missouri
- Columbia University Medical Center — New York, New York
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina
- University Hospitals of Cleveland — Cleveland, Ohio
- Cleveland Clinic — Cleveland, Ohio
- University of Pennsylvania — Philadelphia, Pennsylvania
- VA Puget Sound Health Care System — Seattle, Washington
- Fred Hutchinson Cancer Research Center, UWMC — Seattle, Washington
📞 Contact the Study Coordinator
Phone: (216) 844-5385
Email: axc22@po.cwru.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Barrett's Esophagus
- Surveillance and Image-Guided Biopsy of the Esophagus Using an OFDI Capsule — Boston, Massachusetts
- Enhancing Screening Practices for BE — New Brunswick, New Jersey
- Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry — Kansas City, Missouri
- TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus) — Los Angeles, California
- Navicam for Detection of Barrett's Esophagus — Jacksonville, Florida
- Barrett's Esophagus Related Neoplasia (BERN) Project — Kansas City, Missouri
Explore by condition: All Barrett's Esophagus clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.