Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer (NCT00335816)
Timing of Rectal Cancer Response to Chemoradiation
🩺 Plain-English Summary (8th-Grade Level)
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as fluorouracil, oxaliplatin, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Fluorouracil may also make tumor cells more sensitive to radiation therapy. Leucovorin calcium may protect normal cells from the side effects of chemotherapy, and it may help fluorouracil work better by making tumor cells more sensitive to the drug. Giving radiation therapy together with chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. PURPOSE: This phase II trial is studying how well giving radiation therapy together with fluorouracil with or without combination therapy works in treating patients who are undergoing surgery for stage II or stage III rectal cancer.
Who can join: Review the eligibility criteria below.
Location: Cancer Care Center at John Muir Health - Concord Campus — Concord, California
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (15 Sites)
- Cancer Care Center at John Muir Health - Concord Campus — Concord, California
- City of Hope Medical Center — Duarte, California
- St. Joseph Hospital Regional Cancer Center - Orange — Orange, California
- Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center — Orange, California
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California
- Washington Cancer Institute at Washington Hospital Center — Washington D.C., District of Columbia
- H. Lee Moffitt Cancer Center and Research Institute at University of South Florida — Tampa, Florida
- University of Chicago Cancer Research Center — Chicago, Illinois
- Masonic Cancer Center at University of Minnesota — Minneapolis, Minnesota
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis, Missouri
- Colon and Rectal Surgery, Incorporated — Omaha, Nebraska
- Cleveland Clinic Taussig Cancer Center — Cleveland, Ohio
- Knight Cancer Institute at Oregon Health and Science University — Portland, Oregon
- Vermont Cancer Center at University of Vermont — Burlington, Vermont
- Tom Baker Cancer Centre - Calgary — Calgary, Alberta
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.