RT With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer (NCT00956007)
A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer
🩺 Plain-English Summary (8th-Grade Level)
RATIONALE: Giving radiation therapy that uses a 3-dimensional (3-D) image of the tumor to help focus thin beams of radiation directly on the tumor, and giving radiation therapy in higher doses over a shorter period of time, may kill more tumor cells and have fewer side effects. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether radiation therapy is more effective when given alone or together with cetuximab in treating patients with head and neck cancer that has been removed by surgery. PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (264 Sites)
Showing the first 25 of 264 sites.
- University of Alabama at Birmingham — Birmingham, Alabama
- Arizona Oncology Associates-West Orange Grove — Tucson, Arizona
- Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park, California
- Mercy San Juan Medical Center — Carmichael, California
- City of Hope — Duarte, California
- UC San Diego Moores Cancer Center — La Jolla, California
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California
- Los Angeles County-USC Medical Center — Los Angeles, California
- University of Southern California/Norris Cancer Center — Los Angeles, California
- Memorial Medical Center — Modesto, California
- Bay Area Tumor Institute CCOP — Oakland, California
- Pomona Valley Hospital Medical Center — Pomona, California
- Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville, California
- The Permanente Medical Group-Roseville Radiation Oncology — Roseville, California
- Sutter General Hospital — Sacramento, California
- University of California at Davis Cancer Center — Sacramento, California
- Mercy General Hospital Radiation Oncology Center — Sacramento, California
- UCSF-Mount Zion — San Francisco, California
- Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California
- Saint Helena Hospital — St. Helena, California
- Stanford University Hospitals and Clinics — Stanford, California
- Sutter Cancer Centers Radiation Oncology Services-Vacaville — Vacaville, California
- Rocky Mountain Cancer Centers-Aurora — Aurora, Colorado
- University of Colorado Cancer Center - Anschutz Cancer Pavilion — Aurora, Colorado
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Head and Neck Cancer
- Window Study of Nivolumab With or Without Ipilimumab in Squamous Cell Carcinoma of the Oral Cavity — Boston, Massachusetts
- Imaging With a PET Agent for Detection of Cancers of the Head and Neck — New York, New York
- Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Head and Neck Cancer — Miami, Florida
- ASP-1929 Photoimmunotherapy (PIT) Study in Recurrent Head/Neck Cancer for Patients Who Have Failed at Least Two Lines of Therapy — Miami, Florida
- ASP-1929 Photoimmunotherapy (PIT) Study in Patients With Recurrent Head/Neck Cancer — Bethesda, Maryland
- "QUAD SHOT" Radiotherapy With Pembrolizumab in Patients With Recurrent Head & Neck Cancer — Oklahoma City, Oklahoma
Explore by condition: All Head and Neck Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.