Higher Per Daily Treatment-Dose Radiation Therapy or Standard Per Daily Treatment Radiation Therapy in Treating Patients With Early-Stage Breast Cancer That Was Removed by Surgery (NCT01349322)
A Phase III Trial of Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer
🩺 Plain-English Summary (8th-Grade Level)
RATIONALE: It is not yet know whether higher per daily radiation therapy is equally as effective as standard per daily radiation therapy in treating breast cancer. PURPOSE: This randomized phase III trial studies how well an accelerated course of higher per daily radiation therapy with concomitant boost works compared to standard per daily radiation therapy with a sequential boost in treating patients with early-stage breast cancer that was removed by surgery.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
- Standard fractionation whole breast irradiation (RADIATION)
- Hypofractionated whole breast irradiation (RADIATION)
- Concurrent boost (RADIATION)
- Sequential boost (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (415 Sites)
Showing the first 25 of 415 sites.
- University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
- The Kirklin Clinic at Acton Road — Birmingham, Alabama
- 21st Century Oncology-Scottsdale — Scottsdale, Arizona
- Mayo Clinic in Arizona — Scottsdale, Arizona
- Arizona Oncology Associates-West Orange Grove — Tucson, Arizona
- Banner University Medical Center - Tucson — Tucson, Arizona
- CHI Saint Vincent Cancer Center Hot Springs — Hot Springs, Arkansas
- University of Arkansas for Medical Sciences — Little Rock, Arkansas
- Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park — Cameron Park, California
- Mercy San Juan Medical Center — Carmichael, California
- Enloe Medical Center — Chico, California
- City of Hope Comprehensive Cancer Center — Duarte, California
- Epic Care-Dublin — Dublin, California
- 21st Century Oncology - El Segundo — El Segundo, California
- UC San Diego Moores Cancer Center — La Jolla, California
- Los Angeles County-USC Medical Center — Los Angeles, California
- USC / Norris Comprehensive Cancer Center — Los Angeles, California
- Cedars Sinai Medical Center — Los Angeles, California
- UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California
- Kaiser Permanente Oakland-Broadway — Oakland, California
- Kaiser Permanente-Rancho Cordova Cancer Center — Rancho Cordova, California
- Rohnert Park Cancer Center — Rohnert Park, California
- Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville, California
- The Permanente Medical Group-Roseville Radiation Oncology — Roseville, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Breast Cancer
- S0221 Adjuvant Doxorubicin, Cyclophosphamide, and Paclitaxel in Treating Patients With Breast Cancer — Anniston, Alabama
- [177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer — Los Angeles, California
- Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery — Durham, North Carolina
- TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B) — Palo Alto, California
- A Multi Modality Surveillance Program for Women At High Risk for Breast Cancer — Chicago, Illinois
- ATOP TRIAL: T-DM1 in HER2 Positive Breast Cancer — Duarte, California
Explore by condition: All Breast Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.