๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-04-01

S0820, Adenoma and Second Primary Prevention Trial (NCT01349881)

A Double Blind Placebo-Controlled Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers in Patients With Stage 0-III Colon or Rectal Cancer, Phase III - Preventing Adenomas of the Colon With Eflornithine and Sulindac (PACES)

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: SWOG Cancer Research Network

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

The investigators hypothesize that the combination of eflornithine and sulindac will be effective in reducing a three-year event rate of adenomas and second primary colorectal cancers in patients previously treated for Stages 0 through III colon or rectal cancer.

Who can join: Review the eligibility criteria below.

Location: University of Alabama at Birmingham Cancer Center โ€” Birmingham, Alabama

Age range: 18 Years

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (990 Sites)

Showing the first 25 of 990 sites.

  • University of Alabama at Birmingham Cancer Center โ€” Birmingham, Alabama
  • Anchorage Associates in Radiation Medicine โ€” Anchorage, Alaska
  • Alaska Breast Care and Surgery LLC โ€” Anchorage, Alaska
  • Alaska Oncology and Hematology LLC โ€” Anchorage, Alaska
  • Alaska Regional Hospital โ€” Anchorage, Alaska
  • Alaska Women's Cancer Care โ€” Anchorage, Alaska
  • Katmai Oncology Group โ€” Anchorage, Alaska
  • Providence Alaska Medical Center โ€” Anchorage, Alaska
  • Fairbanks Memorial Hospital โ€” Fairbanks, Alaska
  • Banner MD Anderson Cancer Center โ€” Gilbert, Arizona
  • Cancer Center at Saint Joseph's โ€” Phoenix, Arizona
  • University of Arizona Cancer Center-Orange Grove Campus โ€” Tucson, Arizona
  • Banner University Medical Center - Tucson โ€” Tucson, Arizona
  • University of Arizona Cancer Center-North Campus โ€” Tucson, Arizona
  • CHI Saint Vincent Cancer Center Hot Springs โ€” Hot Springs, Arkansas
  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro โ€” Jonesboro, Arkansas
  • University of Arkansas for Medical Sciences โ€” Little Rock, Arkansas
  • Highlands Oncology Group - Rogers โ€” Rogers, Arkansas
  • Kaiser Permanente-Anaheim โ€” Anaheim, California
  • Kaiser Permanente-Deer Valley Medical Center โ€” Antioch, California
  • Mission Hope Medical Oncology - Arroyo Grande โ€” Arroyo Grande, California
  • Sutter Auburn Faith Hospital โ€” Auburn, California
  • Sutter Cancer Centers Radiation Oncology Services-Auburn โ€” Auburn, California
  • Kaiser Permanente-Baldwin Park โ€” Baldwin Park, California
  • Kaiser Permanente-Bellflower โ€” Bellflower, California

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—