Prostate Advances in Comparative Evidence (NCT01584258)
International Randomised Study of Prostatectomy vs Stereotactic Body Radiotherapy (SBRT) and Conventionally Fractionated Radiotherapy vs SBRT for Organ-Confined Prostate Cancer
🩺 Plain-English Summary (8th-Grade Level)
This study is an international multicentre randomised study of low, intermediate, and high risk prostate cancer and is composed of three parallel randomisation schemes based on applicability of surgery as a treatment for the patient and risk group. Low and intermediate risk patients, for whom surgery is a consideration, are randomised to either prostatectomy or prostate SBRT. Low and intermediate risk patients, for whom surgery is not a consideration, are randomised to either conventionally fractionated radiotherapy or prostate SBRT. Intermediate and high risk patients, for whom ADT treatment is indiacted and surgery is not a consideration, are randomised to either conventionally fractionated radiotherapy or prostate SBRT. Efficacy, toxicity and quality of life outcomes will be compared across the pairs in each randomisation.
Who can join: Review the eligibility criteria below.
Location: Northeast Cancer Centre — Greater Sudbury, Ontario
Age range: 18 Years
🧪 Interventions in This Study
- Prostatectomy (PROCEDURE)
- Conventionally Fractionated Prostate Radiotherapy (RADIATION)
- Prostate SBRT (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (68 Sites)
Showing the first 25 of 68 sites.
- Northeast Cancer Centre — Greater Sudbury, Ontario
- Juravinski Cancer Centre — Hamilton, Ontario
- London Health Sciences Centre — London, Ontario
- Walker Family Cancer Centre — Niagara, Ontario
- Lakeridge Health — Oshawa, Ontario
- The Ottawa Hospital Cancer Centre — Ottawa, Ontario
- Odette Cancer Centre — Toronto, Ontario
- Hôpital Charles-LeMoyne — Montreal, Quebec
- Hôpital Maisonneuve Rosemont — Montreal, Quebec
- Beacon Hospital — Dublin,
- Beaumont Hospital — Dublin,
- St James's Hospital — Dublin,
- St. Luke's Hospital — Dublin,
- Auckland City Hospital — Auckland,
- Hinchingbrooke Hospital — Huntingdon, Cambridgeshire
- Colchester General Hospital — Colchester, Essex
- Churchill Hospital — Oxford, Oxfordshire
- Mount Vernon Cancer Centre — London, Surrey
- Velindre Cancer Centre — Cardiff, Wales
- University Hospital Coventry & Warwickshire NHS Trust — Coventry, West Midlands
- Royal United Hospital — Bath,
- Belfast City Hospital — Belfast,
- Queen Elizabeth Hospital — Birmingham,
- Pilgrim Hospital — Boston,
- Royal Sussex County Hospital — Brighton,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described — Homewood, Alabama
- Stereotactic Ablative Radiation Therapy for Prostate Cancer — Charleston, South Carolina
- A Study of Stereotactic Body Radiation Therapy (SBRT) Without Androgen Deprivation Therapy (ADT) in People With Unfavorable Intermediate-Risk Prostate Cancer — Basking Ridge, New Jersey
- A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer — Phoenix, Arizona
- Neoadjuvant Enoblituzumab (MGA271) in Men With Localized Intermediate and High-Risk Prostate Cancer — Baltimore, Maryland
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.