Investigating Serotonin Signalling in IBD Patients (NCT01650311)
🩺 Plain-English Summary (8th-Grade Level)
Alterations in normal serotonin (5-hydroxytryptamine;5-HT) signaling have been reported in ulcerative colitis (UC) and Crohn's disease (CD). Studies report an increase in enterochromaffin (EC) cell, main source of 5-HT in the gut, numbers in CD and UC patients. Up-regulated expression of mucosal Tryptophan hydroxylase (TPH)-1, catalytic enzyme in 5-HT production, messenger RNA (mRNA) have been found in CD patients in remission who are suffering the irritable bowel syndrome (IBS)-like symptoms. Alterations in normal 5-HT signaling has also been reported in animal models of inflammatory bowel disease (IBD). Thus, the aim of the proposed research project will be to study the alterations in 5-HT signalling accompanying GI inflammatory conditions, such as IBD.
Who can join: Review the eligibility criteria below.
Location: McMaster University Medical Center — Hamilton, Ontario
Age range: 19 Years to 85 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- McMaster University Medical Center — Hamilton, Ontario
📞 Contact the Study Coordinator
Phone: (905) 525-9140
Email: grondij@mcmaster.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Inflammatory Bowel Disease
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- Multi-Center African-American Inflammatory Bowel Disease Study (MAAIS) — Baltimore, Maryland
- The EDICT Trial - Therapy for Inflammatory Bowel Disease Flares — Winston-Salem, North Carolina
- Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease — Bethesda, Maryland
- Immune Regulation in Ulcerative Colitis or Crohn s Disease — Bethesda, Maryland
- A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis — Chicago, Illinois
Explore by condition: All Inflammatory Bowel Disease clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.