Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer (NCT01898494)
Phase II Randomized Trial of Transoral Surgical Resection Followed by Low-Dose or Standard-Dose IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer
🩺 Plain-English Summary (8th-Grade Level)
This randomized phase II trial studies how well transoral surgery followed by low-dose or standard-dose radiation therapy works in treating patients with human papilloma virus (HPV) positive stage III-IVA oropharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy with chemotherapy may kill any tumor cells that remain after surgery. It is not yet known how much extra treatment needs to be given after surgery.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (58 Sites)
Showing the first 25 of 58 sites.
- University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
- Mayo Clinic in Arizona — Scottsdale, Arizona
- University of Arkansas for Medical Sciences — Little Rock, Arkansas
- City of Hope Comprehensive Cancer Center — Duarte, California
- UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California
- Kaiser Permanente Oakland-Broadway — Oakland, California
- Stanford Cancer Institute — Palo Alto, California
- UCSF Medical Center-Mount Zion — San Francisco, California
- Rocky Mountain Cancer Centers-Boulder — Boulder, Colorado
- Penrose-Saint Francis Healthcare — Colorado Springs, Colorado
- Rocky Mountain Cancer Centers-Penrose — Colorado Springs, Colorado
- Porter Adventist Hospital — Denver, Colorado
- Yale University — New Haven, Connecticut
- University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach — Deerfield Beach, Florida
- University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami, Florida
- Florida Hospital Orlando — Orlando, Florida
- Emory University Hospital Midtown — Atlanta, Georgia
- Emory University/Winship Cancer Institute — Atlanta, Georgia
- University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa
- University of Kansas Cancer Center — Kansas City, Kansas
- University of Kentucky/Markey Cancer Center — Lexington, Kentucky
- Greater Baltimore Medical Center — Baltimore, Maryland
- Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore, Maryland
- Brigham and Women's Hospital — Boston, Massachusetts
- Dana-Farber Cancer Institute — Boston, Massachusetts
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Human Papilloma Virus Infection clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.