Pertuzumab and Trastuzumab as Neoadjuvant Treatment in Patients With HER2-Positive Breast Cancer (NCT01937117)
A Phase 2 Clinical Trial Assessing the Correlation of Early Changes in Standardized Uptake Value (SUV) on Positron Emission Tomography (PET) With Pathological Complete Response (pCR) to Pertuzumab and Trastuzumab in Patients With Primary Operable HER2-Positive Breast Cancer
🩺 Plain-English Summary (8th-Grade Level)
This research is being done to determine if early changes on a type of imaging procedure called PET (Positron Emission Tomography) can predict which patients are most likely to respond to the combination of trastuzumab and pertuzumab when given prior to surgery.
Who can join: Review the eligibility criteria below.
Location: University of Alabama Comprehensive Cancer Center — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (10 Sites)
- University of Alabama Comprehensive Cancer Center — Birmingham, Alabama
- Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital — Washington D.C., District of Columbia
- Indiana University Simon Cancer Center — Indianapolis, Indiana
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland
- Mayo Clinic — Rochester, Minnesota
- Lineberger Comprehensive Cancer Center — Chapel Hill, North Carolina
- Vanderbilt University — Nashville, Tennessee
- Baylor College of Medicine — Houston, Texas
- The University of Texas MD Anderson Cancer Center — Houston, Texas
- Fred Hutchinson Cancer Research Center - University of Washington — Seattle, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.