Who is eligible for clinical trial NCT02143466?

Participants must meet protocol criteria for Advanced Non Small Cell Lung Cancer. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT02143466 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-07-17

AZD9291 in Combination With Ascending Doses of Novel Therapeutics (NCT02143466)

A Multi-arm, Phase Ib, Open-Label, Multicentre Study to Assess the Safety,Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9291 in Combination With Ascending Doses of Novel Therapeutics in Patients With EGFRm+ Advanced NSCLC Who Have Progressed Following Therapy With an EGFR TKI (TATTON).

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to determine the safety, tolerability and preliminary anti-tumour activity of AZD9291 when given together with AZD6094 or selumetinib in patients with EGFR mutation positive advanced lung cancer

Who can join: Review the eligibility criteria below.

Location: Research Site — Atlanta, Georgia

Age range: 18 Years to 130 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (42 Sites)

Showing the first 25 of 42 sites.

Research Site — Atlanta, Georgia
Research Site — Boston, Massachusetts
Research Site — Boston, Massachusetts
Research Site — New York, New York
Research Site — Philadelphia, Pennsylvania
Research Site — Nashville, Tennessee
Research Site — Calgary, Alberta
Research Site — Edmonton, Alberta
Research Site — Chūōku,
Research Site — Habikino-shi,
Research Site — Hirakata-shi,
Research Site — Kashiwa,
Research Site — Nagoya,
Research Site — Nagoya,
Research Site — Gdansk,
Research Site — Krakow,
Research Site — Olsztyn,
Research Site — Poznan,
Research Site — Warsaw,
Research Site — Chelyabinsk,
Research Site — Krasnoyarsk,
Research Site — Moscow,
Research Site — Omsk,
Research Site — Saint Petersburg,
Research Site — Saint Petersburg,

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

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Study of Aerosolized Antibiotics and Pembrolizumab in Advanced Non-small Cell Lung Cancer — Bethesda, Maryland

Explore by condition: All Advanced Non Small Cell Lung Cancer clinical trials

💡 How to Participate

Check the checklist above to see if you may qualify.
Review the official NIH record below to find the coordinating site.
Ask about the visit schedule, what is covered at no cost, and any travel support.
Confirm with your own doctor before making a decision.

🏛️ View Official NIH Record ↗