A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer (NCT02246621)
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Nonsteroidal Aromatase Inhibitors (Anastrozole or Letrozole) Plus LY2835219, a CDK4/6 Inhibitor, or Placebo in Postmenopausal Women With Hormone Receptor-Positive, HER2-Negative Locoregionally Recurrent or Metastatic Breast Cancer With No Prior Systemic Therapy in This Disease Setting
🩺 Plain-English Summary (8th-Grade Level)
The main purpose of this study is to evaluate how effective nonsteroidal aromatase inhibitors (NSAI) plus abemaciclib are in postmenopausal women with breast cancer. Participants will be randomized to abemaciclib or placebo in a 2:1 ratio.
Who can join: Review the eligibility criteria below.
Location: Ironwood Cancer & Research Centers — Chandler, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (155 Sites)
Showing the first 25 of 155 sites.
- Ironwood Cancer & Research Centers — Chandler, Arizona
- Highlands Oncology Group — Springdale, Arkansas
- CBCC Global Research, Inc. — Bakersfield, California
- California Cancer Associates Research and Excellence — Fresno, California
- TRIO-US (Translational Research in Oncology-US) — Los Angeles, California
- Central Coast Medical Oncology Corporation — Los Angeles, California
- Orlando Health, Inc — Los Angeles, California
- North Valley Hematology/Oncology Medical Group — Los Angeles, California
- UCLA Hematology/Oncology - Parkside — Santa Monica, California
- Holy Cross Hospital — Fort Lauderdale, Florida
- Lakes Research, LLC — Miami Lakes, Florida
- Candler Medical Oncology Practice - Statesboro — Savannah, Georgia
- Candler Medical Oncology Practice - Statesboro — Savannah, Georgia
- Mayo Clinic in Rochester, Minnesota — Rochester, Minnesota
- Nebraska Hematology-Oncology, P.C. — Lincoln, Nebraska
- Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada
- Mount Sinai Cancer Center — New York, New York
- University of Tennessee Medical Center — Knoxville, Tennessee
- Oncology Consultants P.A. — Houston, Texas
- Joe Arrington Cancer Center — Lubbock, Texas
- Chris O'Brien Lifehouse — Camperdown, New South Wales
- St Vincent's Hospital — Sydney, New South Wales
- Sydney Adventist Hospital — Wahroonga, New South Wales
- Mater Adult Hospital Brisbane — South Brisbane, Queensland
- Princess Alexandra Hospital — Woolloongabba, Queensland
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.