An Efficacy and Safety Study of Apalutamide (JNJ-56021927) in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC) (NCT02257736)
A Phase 3 Randomized, Placebo-controlled Double-blind Study of JNJ-56021927 in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Subjects With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to compare the radiographic progression-free survival (rPFS) of apalutamide in combination with abiraterone acetate (AA) plus prednisone or prednisolone (AAP) and AAP in participants with chemotherapy-naive (participants who did not receive any chemotherapy \[treatment of cancer using drugs\]) metastatic castration-resistant prostate cancer (mCRPC) (cancer of prostate gland \[gland that makes fluid that aids movement of sperm\]).
Who can join: Review the eligibility criteria below.
Location: Clinical Research Facility — Phoenix, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (173 Sites)
Showing the first 25 of 173 sites.
- Clinical Research Facility — Phoenix, Arizona
- Clinical Research Facility — La Mesa, California
- Clinical Research Facility — Los Angeles, California
- Clinical Research Facility — Modesto, California
- Clinical Research Facility — San Diego, California
- Clinical Research Facility — San Francisco, California
- Clinical Research Facility — Santa Barbara, California
- Clinical Research Facility — Aurora, Colorado
- Clinical Research Facility — Denver, Colorado
- Clinical Research Facility — Jensen Beach, Florida
- Clinical Research Facility — Lakeland, Florida
- Clinical Research Facility — New Port Richey, Florida
- Clinical Research Facility — Ocala, Florida
- Clinical Research Facility — Atlanta, Georgia
- Clinical Research Facility — Melrose, Illinois
- Clinical Research Facility — Niles, Illinois
- Clinical Research Facility — Marrero, Louisiana
- Clinical Research Facility — New Orleans, Louisiana
- Clinical Research Facility — Shreveport, Louisiana
- Clinical Research Facility — Auburn, Maine
- Clinical Research Facility — Baltimore, Maryland
- Clinical Research Facility — St Louis, Missouri
- Clinical Research Facility — Omaha, Nebraska
- Clinical Research Facility — Las Vegas, Nevada
- Clinical Research Facility — Albany, New York
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Prostatic Neoplasms
- A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer — Phoenix, Arizona
- PSMA PET/CT for Assessment of Recurrent Prostate Cancer — Vancouver, British Columbia
- An Efficacy and Safety Study of JNJ-56021927 (Apalutamide) in High-risk Prostate Cancer Subjects Receiving Primary Radiation Therapy: ATLAS — Homewood, Alabama
- A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer — Los Angeles, California
- Contributions of a Paramedical Approach in the Prevention and Treatment of Side Effects Associated With Radical Prostatectomy — Fort-de-France,
- A Study of Apalutamide (ARN-509) in Men With Non-Metastatic Castration-Resistant Prostate Cancer — Birmingham, Alabama
Explore by condition: All Prostatic Neoplasms clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.