MelmarT Melanoma Margins Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma (NCT02385214)
A Phase III, Multi-centre, Multi-national Randomised Control Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma
🩺 Plain-English Summary (8th-Grade Level)
Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with a primary invasive cutaneous melanomas \>=1mm thick to determine differences in the rate of local recurrence and melanoma specific survival. A reduction in margins is expected to improve quality of life in patients
Who can join: Review the eligibility criteria below.
Location: Thomas Jefferson University Hospital — Philadelphia, Pennsylvania
Age range: 18 Years
🧪 Interventions in This Study
- Wide Local Excision = 1cm Margin (PROCEDURE)
- Wide Local Excision = 2cm Margin (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (20 Sites)
- Thomas Jefferson University Hospital — Philadelphia, Pennsylvania
- Melanoma Institute Australia - Poche Centre — North Sydney, New South Wales
- Gold Coast Melanom Clinic — Coolangatta, Queensland
- Peter MacCallum Cancer Centre Division of Cancer Surgery — Melbourne, Victoria
- Alfred Hospital — Melbourne, Victoria
- Sunnybrook Health Sciences Centre — Toronto,
- Sahlgrenska University Hospital — Gothenburg,
- Hull and East Yorkshire Hospitals NHS Trust — Hull, England
- Guy's and St Thomas' Hospital NHS Trust — London, England
- The Christie NHS Foundation Trust — Manchester, England
- Mid Essex Hospital Services NHS Trust — Broomfield, Essex
- St Helens & Knowsley NHS Trust — St Helens, Mersyside
- Oxford University Hospitals NHS Trust — Headington, Oxford
- North Bristol NHS Trust — Bristol,
- Cambridge University Hospitals NHS Foundation Trust — Cambridge,
- Royal Devon and Exeter NHS Foundation Trust — Exeter,
- St. James University Hospital — Leeds,
- Royal Free London NHS Foundation Trust — London,
- Imperial College Healthcare NHS Trust — London,
- Norfolk and Norwich University Hospital — Norwich,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Cutaneous Melanoma by AJCC V7 Stage clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.