๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-06-10

Study of Safety and Efficacy of Ceritinib in Combination With Nivolumab in Patients With ALK-positive Non-small Cell Lung Cancer (NCT02393625)

A Multi-center, Open-label Study to Assess the Safety and Efficacy of Combination Ceritinib (LDK378) and Nivolumab in Adult Patients With Anaplastic Lymphoma Kinase (ALK)-Positive Non-small Cell Lung Cancer (NSCLC)

๐Ÿ”ต Active, Not Recruiting Phase1 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: Novartis Pharmaceuticals

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This is an open label multi center trial to determine the safety and efficacy of ceritinib in combination with nivolumab in ALK-positive NSCLC patients

Who can join: Review the eligibility criteria below.

Location: Mayo Clinic - Arizona โ€” Scottsdale, Arizona

Age range: 18 Years to 100 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (12 Sites)

  • Mayo Clinic - Arizona โ€” Scottsdale, Arizona
  • Massachusetts General Hospital โ€” Boston, Massachusetts
  • Massachusetts General Hospital Thoracic Oncolgoy โ€” Boston, Massachusetts
  • Fox Chase Cancer Center โ€” Philadelphia, Pennsylvania
  • Novartis Investigative Site โ€” Heidelberg, Victoria
  • Novartis Investigative Site โ€” Leuven, Vlaams Brabant
  • Novartis Investigative Site โ€” Toronto, Ontario
  • Novartis Investigative Site โ€” Hong Kong,
  • Novartis Investigative Site โ€” Milan, MI
  • Novartis Investigative Site โ€” Modena, MO
  • Novartis Investigative Site โ€” Singapore,
  • Novartis Investigative Site โ€” Barcelona,

๐Ÿ“ž Contact the Study Coordinator

Phone: (800) 664-4580

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in ALK-positive NSCLC

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—