Ischaemic PReconditioning In Non Cardiac surgEry (NCT02427867)
🩺 Plain-English Summary (8th-Grade Level)
Several randomized trials suggested a cardioprotective beneficial effect (eg reduction in cardiac troponin release) of remote ischemic preconditioning in cardiac surgery. Remote ischemic preconditioning by brief episodes of ischemia and reperfusion in a remote organ or vascular territory provides protection from injury by myocardial ischemia and reperfusion. In the translation of remote ischemic preconditioning from bench to bedside, the first proof of principle and small randomized controlled trials have shown a decreased release of myocardial biomarkers after aortic, congenital cardiac, adult valve and coronary artery by-pass graft surgery. This reduction in cardiac biomarkers release translated into better survival in a recent randomized trial performed in cardiac surgery. No clinical trial on remote ischemic preconditioning in non-cardiac surgery setting has been performed so far. The investigators study wants to test, for the first time, the hypothesis that remote ischaemic preconditioning is effective in reducing cardiac damage in high risk patients undergoing non-cardiac surgery. Remote ischaemic preconditioning will be achieved by inflation of a blood-pressure cuff to 200 mm Hg to the upper arm for 5 minutes, followed by 5 minutes reperfusion while the cuff will be deflated. General anesthesia will be induced and maintained without using propofol in both groups. Cardiac troponin will be used as marker of cardiac damage. If the results of a reduction in postoperative cardiac troponin release and perioperative cardiac ischaemic events will be confirmed in a non-cardiac surgery setting, the investigators could improve a strategy to prevent perioperative cardiac complication easy to apply, safe and low cost.
Who can join: Review the eligibility criteria below.
Location: Xijing Hospital — Xi'an
Age range: 50 Years
🧪 Interventions in This Study
- Remote ischemic preconditioning (OTHER)
- no ischemic preconditioning (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (26 Sites)
Showing the first 25 of 26 sites.
- Xijing Hospital — Xi'an,
- Fundación Cardioinfantil-Instituto de Cardiología — Bogotá,
- University Hospital Centre Zagreb — Zagreb,
- Humanitas Clinical Institute — Rozzano, Lombardy
- Valle Olona Po hospital — Busto Arsizio, Varese
- Ospedale Cardinal Massaia — Asti,
- Azienda Ospedaliero Universitaria Careggi — Florence,
- E.O. Ospedali Galliera — Genova,
- IRCCS San Raffaele Scientific Institute — Milan,
- Fondazione IRCCS. Istituto Neurologico Carlo Besta — Milan,
- Università degli studi della Campania Luigi Vanvitelli — Naples,
- Azienda Universitaria Ospedaliero Pisana — Pisa,
- A.O.U. Pisana — Pisa,
- Fondazione Policlinico Universitario Campus Bio-Medico di Roma — Rome,
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS — Rome,
- ULSS 4 Veneto Orientale, Ospedale di San Donà di Piave — San Donà di Piave,
- Azienda Sanitaria Universitaria Friuli Centrale "Santa Maria della Misericordia" — Udine,
- Astana Medical University — Astana,
- Loginov Moscow Clinical Scientific Center — Moscow,
- Oncological Center No. 1 of the S. S. Yudin City Clinical Hospital of the Moscow Department of Health — Moscow,
- I.M. Sechenov First Moscow State Medical — Moscow,
- V.Negovsky Reanimatolgy Research Institute — Moscow,
- Saint-Petersburg State University Hospital — Saint Petersburg,
- Institute of Cardiovascular Diseases "Dedinje" — Belgrade,
- National University Hospital — Singapore,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.