Selection of Allogeneic Hematopoietic Cell Donors Based on KIR and HLA Genotypes (NCT02450708)
🩺 Plain-English Summary (8th-Grade Level)
This study tests whether adding certain genetic factors to the process of picking a stem cell donor can decrease the chances that the patient's leukemia will come back after bone marrow transplantation. Stem cell donors are "matched" based on genes called human leukocyte antigens (HLA). Currently, donors are selected largely on the basis of HLA gene typing alone. There is published data to show that donors with specific other genes called killer immunoglobulin-like receptors (KIR) may protect AML patients from having their leukemia return after a transplant. In this study, the best HLA matched donors will be tested for the KIR genes. If there is more than 1 donor available, a recommendation will be provided to study doctors as to which donors have potentially favorable KIR genes. The study doctors may or may not choose to use this donor for transplant or not based on his/her own judgment. Transplant care will not change otherwise as a result of this study. This study is being done to demonstrate that AML patients who have donors with specific KIR and HLA genes will have a better outcome following transplant.
Who can join: Review the eligibility criteria below.
Location: Moffitt Cancer Center — Tampa, Florida
🧪 Interventions in This Study
- KIR genotyping (GENETIC)
- HLA genotyping (GENETIC)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (10 Sites)
- Moffitt Cancer Center — Tampa, Florida
- Dana Farber Cancer Institute — Boston, Massachusetts
- Mayo Clinic Cancer Center — Rochester, Minnesota
- Hackensack University Medical Center Cancer Center — Hackensack, New Jersey
- Memorial Sloan Kettering Cancer Center — New York, New York
- Duke University Medical Center — Durham, North Carolina
- Ohio State University — Columbus, Ohio
- Baylor University Medical Center — Dallas, Texas
- Md Anderson Cancer Center — Houston, Texas
- University of Washington School of Medicine — Seattle, Washington
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.