Acalabrutinib, Obinutuzumab and Chlorambucil in Treatment naïve CLL (NCT02475681)
A Randomized, Multicenter, Open-Label, 3 Arm Phase 3 Study of Obinutuzumab in Combination With Chlorambucil, Acalabrutinib (ACP-196) in Combination With Obinutuzumab, and Acalabrutinib Monotherapy in Subjects With Previously Untreated CLL
🩺 Plain-English Summary (8th-Grade Level)
This Primary objective is evaluating the efficacy of obinutuzumab in combination with chlorambucil (Arm A) compared with acalabrutinib in combination with obinutuzumab (Arm B) for the treatment of previously untreated chronic lymphocytic leukemia (CLL). Secondary objectives: 1) To evaluate the efficacy of obinutuzumab in combination with chlorambucil (Arm A) versus acalabrutinib monotherapy (Arm C) based on IRC assessment of PFS per IWCLL 2008 criteria. 2)To compare obinutuzumab plus chlorambucil (Arm A) versus acalabrutinib plus obinutuzumab (Arm B) and obinutuzumab plus chlorambucil (Arm A) versus acalabrutinib monotherapy (Arm C) in terms of: IRC-assessed objective response rate (ORR); Tine to next treatment (TTNT); Overall Survival (OS)
Who can join: Review the eligibility criteria below.
Location: Research Site — Goodyear, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (155 Sites)
Showing the first 25 of 155 sites.
- Research Site — Goodyear, Arizona
- Research Site — Phoenix, Arizona
- Research Site — Anaheim, California
- Research Site — Los Angeles, California
- Research Site — Los Angeles, California
- Research Site — Los Angeles, California
- Research Site — Oxnard, California
- Research Site — Palo Alto, California
- Research Site — Aurora, Colorado
- Research Site — Lone Tree, Colorado
- Research Site — Washington D.C., District of Columbia
- Research Site — Fort Myers, Florida
- Research Site — Jacksonville, Florida
- Research Site — Tallahassee, Florida
- Research Site — Tallahassee, Florida
- Research Site — Tampa, Florida
- Research Site — Niles, Illinois
- Research Site — Lafayette, Indiana
- Research Site — Wichita, Kansas
- Research Site — Louisville, Kentucky
- Research Site — New Orleans, Louisiana
- Research Site — COL, Maryland
- Research Site — Rochester, Minnesota
- Research Site — Saint Cloud, Minnesota
- Research Site — Billings, Montana
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Economic Analysis of Alliance A041202 CLL Study — Calgary, Alberta
- A Study of Acalabrutinib vs Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL — Chandler, Arizona
- Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL) — Phoenix, Arizona
Explore by condition: All Chronic Lymphocytic Leukemia clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.