Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer (NCT02488967)
A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel With or Without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer
🩺 Plain-English Summary (8th-Grade Level)
This randomized phase III trial studies how well doxorubicin hydrochloride and cyclophosphamide followed by paclitaxel with or without carboplatin work in treating patients with triple-negative breast cancer. Drugs used in chemotherapy, such as doxorubicin hydrochloride, cyclophosphamide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether doxorubicin hydrochloride and cyclophosphamide is more effective when followed by paclitaxel alone or paclitaxel and carboplatin in treating triple-negative breast cancer.
Who can join: Review the eligibility criteria below.
Location: Southern Cancer Center PC-Mobile — Mobile, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1296 Sites)
Showing the first 25 of 1296 sites.
- Southern Cancer Center PC-Mobile — Mobile, Alabama
- Southern Cancer Center PC-Providence — Mobile, Alabama
- Southern Cancer Center PC-Springhill — Mobile, Alabama
- Anchorage Associates in Radiation Medicine — Anchorage, Alaska
- Anchorage Radiation Therapy Center — Anchorage, Alaska
- Alaska Breast Care and Surgery LLC — Anchorage, Alaska
- Alaska Oncology and Hematology LLC — Anchorage, Alaska
- Alaska Regional Hospital — Anchorage, Alaska
- Alaska Women's Cancer Care — Anchorage, Alaska
- Anchorage Oncology Centre — Anchorage, Alaska
- Katmai Oncology Group — Anchorage, Alaska
- Providence Alaska Medical Center — Anchorage, Alaska
- Fairbanks Memorial Hospital — Fairbanks, Alaska
- Arizona Breast Cancer Specialists-Gilbert — Gilbert, Arizona
- Virginia G Piper Cancer Care-Glendale — Glendale, Arizona
- CTCA at Western Regional Medical Center — Goodyear, Arizona
- Arizona Center for Cancer Care-Peoria — Peoria, Arizona
- Arizona Oncology Associates-Biltmore Cancer Center — Phoenix, Arizona
- Arizona Breast Cancer Specialists-Phoenix — Phoenix, Arizona
- Arizona Oncology-Deer Valley Center — Phoenix, Arizona
- Arizona Breast Cancer Specialists — Scottsdale, Arizona
- Arizona Breast Cancer Specialists-Scottsdale — Scottsdale, Arizona
- Oncogyne PC-Arizona Oncology — Scottsdale, Arizona
- Virginia G Piper Cancer Care-Del Camino — Scottsdale, Arizona
- Sedona Medical Center — Sedona, Arizona
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Breast Adenocarcinoma
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- Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial) — Anniston, Alabama
- Radiation Therapy in Treating Patients With Stage 0-II Breast Cancer — Houston, Texas
- Neoadjuvant Pembrolizumab + Decitabine Followed by Std Neoadj Chemo for Locally Advanced HER2- Breast Ca — Edgewood, Kentucky
- Immune Response to Anti-HER2 Therapies in Patients With HER2-Positive Stage I-IV Breast Cancer — Jacksonville, Florida
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.