Durvalumab With or Without Tremelimumab in Advanced Incurable Solid Malignancies Given With or Without Standard Chemotherapy Regimens (NCT02537418)
A Phase IB Study of Durvalumab (MEDI4736) With or Without Tremelimumab in Patients With Advanced Incurable Solid Malignancies Given With or Without Standard Chemotherapy Regimens
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to find the highest dose of durvalumab or of durvalumab with tremelimumab that can be tolerated without causing very severe side effects when receiving standard chemotherapy and to see what effects the study drugs has on this type of cancer. Patients may receive durvalumab alone or in combination with tremelimumab.
Who can join: Review the eligibility criteria below.
Location: Tom Baker Cancer Centre — Calgary, Alberta
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (7 Sites)
- Tom Baker Cancer Centre — Calgary, Alberta
- BCCA - Vancouver Cancer Centre — Vancouver, British Columbia
- Juravinski Cancer Centre at Hamilton Health Sciences — Hamilton, Ontario
- Cancer Centre of Southeastern Ontario at Kingston — Kingston, Ontario
- Ottawa Hospital Research Institute — Ottawa, Ontario
- University Health Network — Toronto, Ontario
- CHUM - Hopital Notre-Dame — Montreal, Quebec
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Solid Malignancies
- A Phase 1 Study of 177Lu-IM-3050 in Participants With Advanced Cancer — Palo Alto, California
- A Phase 1 Study of IM-1021 in Participants With Advanced Cancer — Duarte, California
- A Modular Phase 1/2 Study With CT7439 in Participants With Solid Malignancies — Dallas, Texas
Explore by condition: All Solid Malignancies clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.