Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) (NCT02568267)
An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements
๐ฉบ Plain-English Summary (8th-Grade Level)
This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.
Who can join: Review the eligibility criteria below.
Location: Dignity Health St Joseph's Hospital and Medical Center โ Phoenix, Arizona
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (120 Sites)
Showing the first 25 of 120 sites.
- Dignity Health St Joseph's Hospital and Medical Center โ Phoenix, Arizona
- Mayo Clinic โ Phoenix, Arizona
- City of Hope Cancer Center โ Duarte, California
- City of Hope Duarte - Comprehensive Cancer Center, Investigational Drug Services โ Duarte, California
- Scripps Clinic โ La Jolla, California
- University of California San Diego Moores Cancer Center โ La Jolla, California
- Southern California Kaiser Permanente โ Los Angeles, California
- Univ Of California Irvine College Of Medicine โ Orange, California
- UCSF Mount Zion Medical Ctr โ San Francisco, California
- UCSF Mission Bay โ San Francisco, California
- Sarcoma Oncology Center โ Santa Monica, California
- Sarcoma Oncology Research Center LLC โ Santa Monica, California
- University of Colorado Cancer Center โ Aurora, Colorado
- Yale University โ New Haven, Connecticut
- Georgetown University Medical Center Lombardi Cancer Center โ Washington D.C., District of Columbia
- Florida Cancer Specialists - Sarasota โ Sarasota, Florida
- H. Lee Moffitt Cancer Center and Research Inst. โ Tampa, Florida
- Moffitt Cancer Center โ Tampa, Florida
- University Cancer & Blood Center, LLC โ Athens, Georgia
- Winship Cancer Institute โ Atlanta, Georgia
- Southeastern Regional Medical Center, Inc. โ Newnan, Georgia
- Northwestern University โ Chicago, Illinois
- Advocate Medical Group - Park Ridge, Luther Lane - Oncology โ Park Ridge, Illinois
- Midwestern Regional Medical Center โ Zion, Illinois
- Weinberg Cancer Institution at Franklin Square โ Baltimore, Maryland
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.