M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery (NCT02595931)
Phase I Clinical Trial of M6620 (VX-970, Berzosertib) in Combination With the Topoisomerase I Inhibitor Irinotecan in Patients With Advanced Solid Tumors
๐ฉบ Plain-English Summary (8th-Grade Level)
This phase I trial studies the side effects and best dose of M6620 and irinotecan hydrochloride in treating patients with solid tumors that have spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). M6620 and irinotecan hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Who can join: Review the eligibility criteria below.
Location: Los Angeles General Medical Center โ Los Angeles, California
Age range: 18 Years
๐งช Interventions in This Study
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (23 Sites)
- Los Angeles General Medical Center โ Los Angeles, California
- USC / Norris Comprehensive Cancer Center โ Los Angeles, California
- Stanford Cancer Institute Palo Alto โ Palo Alto, California
- Keck Medical Center of USC Pasadena โ Pasadena, California
- University of California Davis Comprehensive Cancer Center โ Sacramento, California
- UCSF Medical Center-Mount Zion โ San Francisco, California
- Smilow Cancer Center/Yale-New Haven Hospital โ New Haven, Connecticut
- Yale University โ New Haven, Connecticut
- UF Health Cancer Institute - Gainesville โ Gainesville, Florida
- Massachusetts General Hospital Cancer Center โ Boston, Massachusetts
- Brigham and Women's Hospital โ Boston, Massachusetts
- Beth Israel Deaconess Medical Center โ Boston, Massachusetts
- Dana-Farber Cancer Institute โ Boston, Massachusetts
- Wayne State University/Karmanos Cancer Institute โ Detroit, Michigan
- Siteman Cancer Center at Saint Peters Hospital โ City of Saint Peters, Missouri
- Siteman Cancer Center at West County Hospital โ Creve Coeur, Missouri
- Washington University School of Medicine โ St Louis, Missouri
- Siteman Cancer Center-South County โ St Louis, Missouri
- Siteman Cancer Center at Christian Hospital โ St Louis, Missouri
- UNC Lineberger Comprehensive Cancer Center โ Chapel Hill, North Carolina
- UPMC Hillman Cancer Center โ Pittsburgh, Pennsylvania
- Vanderbilt Breast Center at One Hundred Oaks โ Nashville, Tennessee
- Vanderbilt University/Ingram Cancer Center โ Nashville, Tennessee
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinoma โ Birmingham, Alabama
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๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.