🏛️ Verified NIH Record • Updated 2025-11-04
Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients With Non-Metastatic Breast Cancer: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial (NCT02603341)
🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol Sponsor: Abramson Cancer Center at Penn Medicine
🩺 Plain-English Summary (8th-Grade Level)
A pragmatic randomized clinical trial of patients with locally advanced breast cancer randomized to either proton or photon therapy and followed longitudinally for cardiovascular morbidity and mortality, health-related quality of life, and cancer control outcomes. Quality of life is the outcome measure for the estimated primary completion date of December, 2024, www.radcomp.org.
Who can join: Review the eligibility criteria below.
Location: University of Alabama — Birmingham, Alabama
Age range: 21 Years
🧪 Interventions in This Study
- Photon (RADIATION)
- Proton (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (40 Sites)
Showing the first 25 of 40 sites.
- University of Alabama — Birmingham, Alabama
- Mayo Clinic-Arizona — Phoenix, Arizona
- UC San Diego — San Diego, California
- Georgetown University Medical Center — Washington D.C., District of Columbia
- University of Miami Sylvester Cancer Center at Coral Gables — Coral Gables, Florida
- University of Miami Sylvester Cancer Center - Deerfield — Deerfield Beach, Florida
- University of Florida Health — Gainesville, Florida
- University of Florida Health Proton Therapy Institute — Jacksonville, Florida
- University of Miami Sylvester Cancer Center — Miami, Florida
- Miami Cancer Insititute — Miami, Florida
- Orlando Health — Orlando, Florida
- Emory University — Atlanta, Georgia
- Northwestern Medicine Proton Center — Chicago, Illinois
- Willis Knighton — Shreveport, Louisiana
- University of Maryland — Baltimore, Maryland
- Johns Hopkins — Baltimore, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- Mass General/North Shore Cancer Center — Danvers, Massachusetts
- McLaren Proton Therapy — Flint, Michigan
- William Beaumont — Royal Oak, Michigan
- Mayo Clinic-Rochester — Rochester, Minnesota
- Washington University, St. Louis — St Louis, Missouri
- RWJ University Hospital Hamilton — Hamilton, New Jersey
- Cancer Institute of NJ — New Brunswick, New Jersey
- ProCure Proton Therapy Center — Somerset, New Jersey
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.