🏛️ Verified NIH Record • Updated 2026-06-15
Plasma ExtrAcellular RNAs and Biomarkers of Heart FaiLure During Decongestion: PEARL-HF Study (NCT02632656)
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Massachusetts General Hospital
🩺 Plain-English Summary (8th-Grade Level)
The primary objective is to measure the association between extracellular RNA (ex-RNA) levels in plasma in patients receiving aggressive outpatient therapy for CHF with (1) cardiac remodeling and (2) cardiovascular events. The investigators will follow patients during standard medical therapy for CHF to assess changes in ex-RNA levels in the plasma, and how these are associated with cardiac remodeling (by cardiac imaging) and outcomes.
Who can join: Review the eligibility criteria below.
Location: Massachusetts General Hospital — Boston, Massachusetts
Age range: 21 Years to 100 Years
🧪 Interventions in This Study
- Monitoring on heart failure therapy (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Massachusetts General Hospital — Boston, Massachusetts
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Congestive Heart Failure
- SyncAV Post-Market Trial — Huntsville, Alabama
- Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure — Birmingham, Alabama
- Boston Medical Center Ultrasound Decongestion Study in Heart Failure — Boston, Massachusetts
- Palliative Care for People With HF — Indianapolis, Indiana
- Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease — Murray, Utah
Explore by condition: All Congestive Heart Failure clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.