Evaluation of Biomarkers in Human Synovial Fluid (NCT02664870)
Prospective Biological and Clinical Databank for the Evaluation of Biomarkers in Human Synovial Fluid
🩺 Plain-English Summary (8th-Grade Level)
Osteoarthritis is a condition that causes joints in the human body to deteriorate over time. This condition affects more than 250 million people around the globe. Currently, the goal of treating osteoarthritis involves reducing the severity and pain that results from the disease. The ultimate goal of this study is to identify patients with pre-arthritic joints (before symptoms or disease characteristics appear) in an effort to find and use treatments that stop or slow the disease. Joints are filled with a naturally occurring liquid known as synovial fluid. Molecules (biomarkers) and genetic expression of various cell types within synovial joint fluid may serve as measures of onset and progression of osteoarthritis. These samples have the potential to improve diagnosis, classification, and treatment, possibly changing the natural history of this debilitating disease. The purpose of this study is to develop a collection of synovial fluid samples from the shoulder, hip and knee for the analysis of biomarkers and cellular and genetic components therein to better understand the pre-arthritic joint, progression to disease, and response to interventions.
Who can join: Review the eligibility criteria below.
Location: Duke Orthopaedic Clinics — Durham, North Carolina
Age range: 18 Years
🧪 Interventions in This Study
- Arthroscopy (PROCEDURE)
- Arthroplasty (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (1 Sites)
- Duke Orthopaedic Clinics — Durham, North Carolina
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA) — Miami, Florida
- Persona Partial Knee Clinical Outcomes Study — Fremont, California
- Comprehensive Nano - Post Market Clinical Follow-Up Study — Graz, Styria
Explore by condition: All Osteoarthritis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.