🏛️ Verified NIH Record • Updated 2025-12-19
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis (NCT02675114)
A Prospective, Randomized, Controlled, Multi-Center Study to Establish the Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients Who Have Severe, Calcific, Aortic Stenosis Requiring Aortic Valve Replacement
🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: Edwards Lifesciences
🩺 Plain-English Summary (8th-Grade Level)
To establish the safety and effectiveness of the Edwards SAPIEN 3 Transcatheter Heart Valve (THV) in patients with severe, calcific aortic stenosis who are at low operative risk for standard aortic valve replacement.
Who can join: Review the eligibility criteria below.
Location: University of Alabama — Birmingham, Alabama
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (77 Sites)
Showing the first 25 of 77 sites.
- University of Alabama — Birmingham, Alabama
- Banner University Medical Center — Phoenix, Arizona
- Mills/Peninsula Health Services — Burlingame, California
- Cedars-Sinai Medical Center — Los Angeles, California
- University of California, Los Angeles/Ronald Reagan Medical Center — Los Angeles, California
- Hoag Hospital — Newport Beach, California
- Stanford Hospital and Clinics — Palo Alto, California
- Sutter Health Sacramento — Sacramento, California
- Kaiser Permanente San Francisco — San Francisco, California
- UC Health Northern Colorado/Medical Center of the Rockies — Loveland, Colorado
- Hartford — Hartford, Connecticut
- JFK Medical Center / Atlantic Clinical Research Collaborative — Atlantis, Florida
- University of Florida, Gainesville — Gainesville, Florida
- Mount Sinai Medical Center — Miami Beach, Florida
- Florida Hospital — Orlando, Florida
- Emory University — Atlanta, Georgia
- The Queen's Medical Center — Honolulu, Hawaii
- Northwestern University — Chicago, Illinois
- Rush University Medical Center — Chicago, Illinois
- NorthShore University HealthSystem Research Institute — Evanston, Illinois
- Prairie Education and Research Cooperative — Springfield, Illinois
- University of Iowa Hospitals and Clinics — Iowa City, Iowa
- Cardiovascular Research Institute of Kansas — Wichita, Kansas
- UPR - Louisiana State University Health Science Center — New Orleans, Louisiana
- Ochsner Clinic Foundation — New Orleans, Louisiana
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Aortic Stenosis
- PERIGON Pivotal Trial — Los Angeles, California
- ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement — Birmingham, Alabama
- Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study — Tucson, Arizona
- Application of TAVI at Experienced Interventional Cardiac Centers Without On-site Cardiac Surgery (ATLAS Study) — Edmonton, Alberta
- Systematic Ambulatory ECG Monitoring Following TAVI — Québec, Quebec
Explore by condition: All Aortic Stenosis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.