Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (NCT02735707)
๐ฉบ Plain-English Summary (8th-Grade Level)
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia. In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19. REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19 in the United States of America.
Who can join: Review the eligibility criteria below.
Location: University of Florida โ Jacksonville, Florida
Age range: 18 Years
๐งช Interventions in This Study
- Ceftriaxone (DRUG)
- Moxifloxacin or Levofloxacin (DRUG)
- Piperacillin-tazobactam (DRUG)
- Ceftaroline (DRUG)
- Amoxicillin-clavulanate (DRUG)
- Standard course macrolide (DRUG)
- Extended course macrolide (DRUG)
- Fixed-duration Hydrocortisone (DRUG)
- Shock-dependent hydrocortisone (DRUG)
- Fixed-duration higher dose Hydrocortisone (DRUG)
- Five-days oseltamivir (DRUG)
- Ten-days oseltamivir (DRUG)
- Lopinavir / Ritonavir (DRUG)
- Hydroxychloroquine (DRUG)
- Hydroxychloroquine + lopinavir/ritonavir (DRUG)
- Ivermectin (DRUG)
- Interferon beta-1a (DRUG)
- Anakinra (DRUG)
- Tocilizumab (DRUG)
- Sarilumab (DRUG)
- Local standard venous thromboprophylaxis (DRUG)
- Therapeutic dose anticoagulation (DRUG)
- Conventional low dose thromboprophylaxis (DRUG)
- Intermediate dose thromboprophylaxis (DRUG)
- Continuation of therapeutic dose anticoagulation (DRUG)
- Convalescent plasma (BIOLOGICAL)
- Delayed administration of convalescent plasma (BIOLOGICAL)
- Vitamin C (DRUG)
- Aspirin (DRUG)
- P2Y12 inhibitor (DRUG)
- Simvastatin (DRUG)
- Eritoran (DRUG)
- Apremilast (DRUG)
- Angiotensin converting enzyme inhibitor (DRUG)
- Angiotensin Receptor Blockers (DRUG)
- ARB + DMX-200 (DRUG)
- Cysteamine (DRUG)
- Fixed-duration dexamethasone (DRUG)
- Baloxavir Marboxil (DRUG)
- Five-days oseltamivir + baloxavir marboxil (DRUG)
- Ten-days oseltamivir + baloxavir marboxil (DRUG)
- Imatinib (DRUG)
- Tocilizumab (DRUG)
- Baricitinib (DRUG)
- Nirmatrelvir/ritonavir (DRUG)
- Remdesivir (DRUG)
- Nirmatrelvir/ritonavir + remdesivir (DRUG)
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria โ
๐ All Participating Trial Locations (408 Sites)
Showing the first 25 of 408 sites.
- University of Florida โ Jacksonville, Florida
- Augusta University โ Augusta, Georgia
- University of Illinois Health โ Chicago, Illinois
- Tulane Medical Center โ New Orleans, Louisiana
- University of Michigan โ Ann Arbor, Michigan
- Memorial Sloan Kettering Cancer Center โ New York, New York
- Wake Forest Baptist Health โ Winston-Salem, North Carolina
- The Ohio State University Wexner Medical Center โ Columbus, Ohio
- Oregon Health and Science University โ Portland, Oregon
- University of Pittsburgh Medical Centre โ Pittsburgh, Pennsylvania
- Brown University - Rhode Island Hospital โ Providence, Rhode Island
- Canberra Hospital โ Canberra, Australian Capital Territory
- Bankstown-Lidcombe Hospital โ Bankstown, New South Wales
- Blacktown Hospital โ Blacktown, New South Wales
- Campbelltown Hospital โ Campbelltown, New South Wales
- Sutherland Hospital โ Caringbah, New South Wales
- Concord Hospital โ Concord, New South Wales
- Dubbo Base Hospital โ Dubbo, New South Wales
- Northern Beaches Hospital โ Frenchs Forest, New South Wales
- Nepean Hospital โ Kingswood, New South Wales
- St. George Hospital โ Kogarah, New South Wales
- Liverpool Hospital โ Liverpool, New South Wales
- John Hunter Hospital โ Newcastle, New South Wales
- Orange Health Service โ Orange, New South Wales
- St Vincent's Hospital Sydney โ Sydney, New South Wales
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Community-acquired Pneumonia, Influenza, COVID-19 clinical trials
๐ก How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.