Critical Health Assessment and Outcomes Score/Study (NCT02766166)
🩺 Plain-English Summary (8th-Grade Level)
CHAOS is based on the investigator's new and exciting results from pre-clinical and large longitudinal multi-center observational clinical studies of critically ill patients and asymptomatic community-based adults with little or no advanced disease. By integrating approaches from the physical, biological, computational, statistical and clinical sciences, this observational study will test the hypothesis that early diagnosis of subclinical signatures of critical illness encoded within physiological signals complements conventional clinical predictors by providing unique prognostic insight. The primary goal is to reduce mortality, morbidity and complications by early identification of individuals with brewing subclinical critical illness and adverse events before overt clinical presentation (e.g., cardiac arrest, arrhythmias, hemorrhage, respiratory failure, circulatory collapse). This will provide the necessary lead time for healthcare providers to deliver early, more effective and/or preventive therapies. Through innovative approaches, CHAOS also meets the challenge of medical errors to reduce missed diagnosis, misdiagnosis, preventable harm and variability in provider adherence to best practice guidelines. The goal is to validate predictive algorithms and identify subclinical signatures of illness, ranging from asymptomatic adults in the community to very sick patients in the hospital. The overall goal is to make healthcare more precise, effective, efficient, safe and timely while reducing costs, preventable harms and adverse events.
Who can join: Review the eligibility criteria below.
Location: Indiana University — Indianapolis, Indiana
Age range: 18 Years
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (3 Sites)
- Indiana University — Indianapolis, Indiana
- Johns Hopkins University — Baltimore, Maryland
- University of Cincinnati — Cincinnati, Ohio
📞 Contact the Study Coordinator
Phone: (513) 558-1035
Email: DDeMazu@iu.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Critical Illness
- 12-hour Time Limited Feeding in Critical Care — Kansas City, Kansas
- Strategy to Avoid Excessive Oxygen in Major Burn Patients — Birmingham, Alabama
- Family Integration in Therapy Activities in the Intensive Care Unit: The FIT-ICU Feasibility Study — Brantford, Ontario
- Real-time NOMA Evaluation — Pittsburgh, Pennsylvania
- Amino Acid Nutrition in the Critically-ill — Montreal, Quebec
- Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors — Seattle, Washington
Explore by condition: All Critical Illness clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.