🏛️ Verified NIH Record • Updated 2025-10-08
eXalt3: Study Comparing X-396 (Ensartinib) to Crizotinib in ALK Positive Non-Small Cell Lung Cancer (NSCLC) Patients (NCT02767804)
Phase 3 Randomized Study Comparing X-396 (Ensartinib) to Crizotinib in Anaplastic Lymphoma Kinase (ALK) Positive Non-Small Cell Lung Cancer (NSCLC) Patients
🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Xcovery Holdings, Inc.
🩺 Plain-English Summary (8th-Grade Level)
The primary purpose of this study is to evaluate the efficacy and safety of X-396 (ensartinib) vs. crizotinib in patients with ALK-positive non-small cell lung cancer that have received up to 1 prior chemotherapy regimen and no prior ALK inhibitor.
Who can join: Review the eligibility criteria below.
Location: Moffitt Cancer Center — Tampa, Florida
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (72 Sites)
Showing the first 25 of 72 sites.
- Moffitt Cancer Center — Tampa, Florida
- University Cancer & Blood Center — Athens, Georgia
- Washington University School of Medicine — St Louis, Missouri
- Providence Portland Medical Center — Portland, Oregon
- Sanatorio Parque S.A. — Rosario,
- Border Medical Oncology Research Unit — Albury, New South Wales
- Chris O'Brien Lifehouse — Camperdown, New South Wales
- Chris O Brien Lifehouse — Camperdown,
- Catholic University of Louvain (UCL) - Site Mont Godinne — Yvoir,
- Instituto do Câncer do Estado de São Paulo — São Paulo, São Paulo
- Hospital de Câncer de Barretos - Fundação Pio XII — São Paulo, São Paulo
- Hospital Haroldo Juaçaba - Instituto do Cancêr do Ceará — Fortaleza,
- Fundacao do ABC Faculdade de Medicina do ABC — São Paulo,
- Infirmière recherche Clinique, IUCPQ — Québec, Quebec
- Anhui Provincial Hospital — Hefei, Anhui
- Beijing Chao Yang Hospital — Beijing, Beijing Municipality
- Peking Union Medical College Hospital — Beijing, Beijing Municipality
- Peking University Cancer Hospital — Beijing, Beijing Municipality
- Beijing Chest Hospital,Capital Medical University — Beijing, Beijing Municipality
- Fujian Provincial Cancer Hospital — Fuzhou, Fujian
- Guangdong General Hospital — Guangzhou, Guangdong
- Fourth Hospital of Hebei Medical University — Shijiazhuang, Hebei
- Hunan Cancer Hospital — Changsha, Hu'nan
- Union Hospital of Tongji Medical College of Huazhong Science and Techology University — Wuhan, Hubei
- Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology — Wuhan, Hubei
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Non-small Cell Lung Cancer
- Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations — Birmingham, Alabama
- Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1) — La Jolla, California
- PhI/II Study of Amivantamab and Tepotinib Combo in MET-altered Non-small Cell Lung Cancer — Houston, Texas
- Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer — Renton, Washington
- Osimertinib and Gefitinib in EGFR Inhibitor naïve Advanced EGFR Mutant Lung Cancer — Boston, Massachusetts
- Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01) — Chandler, Arizona
Explore by condition: All Non-small Cell Lung Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.