A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers (NCT02908906)
63723283LUC1001: A First-in-Human, Open-label, Phase 1/2 Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Subjects With Advanced Cancers
🩺 Plain-English Summary (8th-Grade Level)
The Primary purpose of this study is to identify the recommended Phase 2 dose \[RP2D(s)\] for JNJ-63723283 in Part 1, to assess the anti-tumor activity of JNJ-63723283 at the RP2D(s) in participants with selected advanced cancers including non-small-cell lung cancer (NSCLC), melanoma, renal, bladder, small-cell lung cancer (SCLC), gastric/esophageal cancer, and high-level microsatellite instability (MSI-H) or mismatch repair-deficient (dMMR) colorectal cancer (CRC) in Part 2, to determine one or more additional RP2Ds in Parts 3 and 4.
Who can join: Review the eligibility criteria below.
Location: Clinical Research Facility — St Louis, Missouri
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (20 Sites)
- Clinical Research Facility — St Louis, Missouri
- Clinical Research Facility — Pittsburgh, Pennsylvania
- Clinical Research Facility — Chisinau,
- Clinical Research Facility — Bialystok,
- Clinical Research Facility — Warsaw,
- Clinical Research Facility — Moscow,
- Clinical Research Facility — Pyatigorsk,
- Clinical Research Facility — Saint Petersburg,
- Clinical Research Facility — Badalona,
- Clinical Research Facility — Barcelona,
- Clinical Research Facility — Madrid,
- Clinical Research Facility — Málaga,
- Clinical Research Facility — Pamplona,
- Clinical Research Facility — Seville,
- Clinical Research Facility — Valencia,
- Clinical Research Facility — Gothenburg,
- Clinical Research Facility — Glasgow,
- Clinical Research Facility — London,
- Clinical Research Facility — Manchester,
- Clinical Research Facility — Newcastle upon Tyne,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.