Hypofractionated vs. Conventional Regional Nodal Radiation Therapy for Patients With Invasive Breast Cancer (NCT02912312)
Shortening Adjuvant Photon Irradiation to Reduce Edema (SAPHIRE): A Randomized Trial of Hypofractionated Versus Conventionally Fractionated Regional Nodal Irradiation for Invasive Breast Cancer
🩺 Plain-English Summary (8th-Grade Level)
To compare how often cancer recurs (comes back) after 3 weeks of radiation compared to 5 weeks of radiation in patients who receive radiation therapy delivered to the lymph nodes near the breast. The side effects that can develop during or after radiation treatment, including how often arm swelling (edema) happens, will also be studied.
Who can join: Review the eligibility criteria below.
Location: MD Anderson Cancer Center (Banner) — Gilbert, Arizona
Age range: 18 Years
🧪 Interventions in This Study
- Hypofractionated Radiation Therapy (RADIATION)
- Laboratory Biomarker Analysis (OTHER)
- Quality-of-Life Assessment (OTHER)
- Questionnaire Administration (OTHER)
- Radiation Therapy (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (12 Sites)
- MD Anderson Cancer Center (Banner) — Gilbert, Arizona
- Scripps- MD Anderson Cancer — San Diego, California
- MD Anderson Cancer Center (Banner)- Northern Colorado — Greeley, Colorado
- Baptist - MD Anderson Cancer Center — Jacksonville, Florida
- Orlando Health Cancer Institute — Orlando, Florida
- Community MD Anderson Cancer Center East — Indianapolis, Indiana
- Community MD Anderson Cancer Center South — Indianapolis, Indiana
- Community MD Anderson Cancer Center North — Indianapolis, Indiana
- Cooper Hospital University Medical Center — Camden, New Jersey
- Ohio Health — Columbus, Ohio
- M D Anderson Cancer Center — Houston, Texas
- UT Health San Antonio - MD Anderson Cancer Center — San Antonio, Texas
📞 Contact the Study Coordinator
Phone: (877) 632-6789
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Invasive Breast Carcinoma
- Molecular Testing and Imaging in Improving Response in Patients With Stage I-III Triple-Negative Breast Cancer Receiving Chemotherapy MDACC Breast Moonshot Initiative — Conroe, Texas
- Impact of Neoadjuvant Chemotherapy on the Peripheral Blood Immune Phenotype in Operable Breast Cancer — Rochester, Minnesota
- Carboplatin and Paclitaxel With or Without Atezolizumab Before Surgery in Treating Patients With Newly Diagnosed, Stage II-III Triple-Negative Breast Cancer — Phoenix, Arizona
Explore by condition: All Invasive Breast Carcinoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.