Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS (NCT02926911)
Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS: A Phase III Prospective Randomized Trial
🩺 Plain-English Summary (8th-Grade Level)
This study looks at the risks and benefits of active monitoring (AM) compared to surgery in the setting of a pragmatic prospective randomized trial for low risk DCIS. Our overarching hypothesis is that management of low-risk Ductal Carcinoma in Situ (DCIS) using an AM approach does not yield inferior cancer or quality of life outcomes compared to surgery.
Who can join: Review the eligibility criteria below.
Location: Providence Alaska Medical Center — Anchorage, Alaska
Age range: 40 Years to 99 Years
🧪 Interventions in This Study
- Surgery (OTHER)
- Active Monitoring (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (141 Sites)
Showing the first 25 of 141 sites.
- Providence Alaska Medical Center — Anchorage, Alaska
- Mayo Clinic — Phoenix, Arizona
- City of Hope — Duarte, California
- Cedars-Sinai Medical Center — Los Angeles, California
- Sharp Memorial Hospital — San Diego, California
- Kaiser Permanente Medical Center — Vallejo, California
- Colorado Cancer Research Program — Denver, Colorado
- Saint Joseph Hospital- Cancer Centers of Colorado — Lafayette, Colorado
- Smilow Cancer Hospital at Yale-New Haven — New Haven, Connecticut
- MedStar Washington Hospital Center — Washington D.C., District of Columbia
- Memorial Healthcare System — Hollywood, Florida
- Mayo Clinic Florida — Jacksonville, Florida
- University of Hawaii Cancer Center — Honolulu, Hawaii
- Kootenai Health — Post Falls, Idaho
- John H Stroger Jr Hospital of Cook County — Chicago, Illinois
- University of Chicago Medical Center — Chicago, Illinois
- Advocate Illinois Masonic Medical Center — Chicago, Illinois
- NorthShore University HealthSystem-Evanston Hospital — Evanston, Illinois
- Ingalls Memorial Hospital — Harvey, Illinois
- Illinois Cancer Care — Peoria, Illinois
- OSF Saint Anthony Medical Center — Rockford, Illinois
- Carle Cancer Center — Urbana, Illinois
- Medical Oncology and Hematology Associates - Des Moines — Des Moines, Iowa
- University of Iowa/Holden Comprehensive Cancer Center — Iowa City, Iowa
- University of Kansas Cancer Center — Kansas City, Kansas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in DCIS
- Prospective Evaluation of Breast-Conserving Surgery Alone in Low-Risk Ductal Carcinoma in Situ (DCIS) — Calgary, Alberta
- The PREDICT Registry: — Scottsdale, Arizona
- Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ — Houston, Texas
Explore by condition: All DCIS clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.