A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS) (NCT02991469)
An Open-label, Sequential, Ascending, Repeated Dose-finding Study of Sarilumab, Administered With Subcutaneous (SC) Injection, in Children and Adolescents, Aged 1 to 17 Years, With Systemic Juvenile Idiopathic Arthritis (sJIA), Followed by an Extension Phase
🩺 Plain-English Summary (8th-Grade Level)
Primary Objective: To describe the pharmacokinetic (PK) profile of sarilumab in patients aged 1-17 years with Systemic Juvenile Idiopathic Arthritis (sJIA) in order to identify the dose and regimen for adequate treatment of this population. Secondary Objective: To describe the pharmacodynamics (PD) profile, the efficacy, and the long term safety of sarilumab in patients with sJIA.
Who can join: Review the eligibility criteria below.
Location: Investigational Site Number : 0320004 — San Miguel de Tucumán, Tucumán Province
Age range: 1 Year to 17 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (32 Sites)
Showing the first 25 of 32 sites.
- Investigational Site Number : 0320004 — San Miguel de Tucumán, Tucumán Province
- Investigational Site Number : 0320005 — Buenos Aires,
- Investigational Site Number : 1240110 — Calgary, Alberta
- Investigational Site Number : 2460040 — Helsinki,
- Investigational Site Number : 2500041 — Bron,
- Investigational Site Number : 2500042 — Montpellier,
- Investigational Site Number : 2500040 — Paris,
- Investigational Site Number : 2760064 — Berlin,
- Investigational Site Number : 2760065 — Berlin,
- Investigational Site Number : 2760062 — Hamburg,
- Investigational Site Number : 2760060 — Sankt Augustin,
- Investigational Site Number : 2760063 — Sendenhorst,
- Investigational Site Number : 3000001 — Athens,
- Investigational Site Number : 3000002 — Thessaloniki,
- Investigational Site Number : 3720001 — Crumlin, Dublin
- Investigational Site Number : 3800051 — Genoa, Genova
- Investigational Site Number : 3800054 — Milan, Milano
- Investigational Site Number : 3800052 — Rome, Roma
- Investigational Site Number : 6200003 — Lisbon,
- Investigational Site Number : 6430001 — Moscow,
- Investigational Site Number : 6430062 — Moscow,
- Investigational Site Number : 6430063 — Moscow,
- Investigational Site Number : 6430065 — Ufa,
- Investigational Site Number : 7240055 — Barcelona, Barcelona [Barcelona]
- Investigational Site Number : 7240050 — Esplugues de Llobregat, Barcelona [Barcelona]
📞 Contact the Study Coordinator
Phone: (800) 633-1610
Email: Contact-Us@sanofi.com
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Juvenile Idiopathic Arthritis
- An Observational Registry of Abatacept in Patients With Juvenile Idiopathic Arthritis — Little Rock, Arkansas
- Study of Oral Upadacitinib and Subcutaneous/Intravenous Tocilizumab to Evaluate Change in Disease Activity, Adverse Events and How Drug Moves Through the Body of Pediatric and Adolescent Participants With Active Systemic Juvenile Idiopathic Arthritis. — Phoenix, Arizona
- A Study of Baricitinib in Participants From 1 Year to Less Than 18 Years Old With Juvenile Idiopathic Arthritis — Rosario,
- M3-JIA: Making Mindfulness Matter for Children With JIA — Hamilton, Ontario
- UCAN CAN-DU: Canada-Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic Disease — Calgary, Alberta
Explore by condition: All Juvenile Idiopathic Arthritis clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.