🏛️ Verified NIH Record • Updated 2026-05-20

A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (SKYPS) (NCT02991469)

An Open-label, Sequential, Ascending, Repeated Dose-finding Study of Sarilumab, Administered With Subcutaneous (SC) Injection, in Children and Adolescents, Aged 1 to 17 Years, With Systemic Juvenile Idiopathic Arthritis (sJIA), Followed by an Extension Phase

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Sanofi

🩺 Plain-English Summary (8th-Grade Level)

Primary Objective: To describe the pharmacokinetic (PK) profile of sarilumab in patients aged 1-17 years with Systemic Juvenile Idiopathic Arthritis (sJIA) in order to identify the dose and regimen for adequate treatment of this population. Secondary Objective: To describe the pharmacodynamics (PD) profile, the efficacy, and the long term safety of sarilumab in patients with sJIA.

Who can join: Review the eligibility criteria below.

Location: Investigational Site Number : 0320004 — San Miguel de Tucumán, Tucumán Province

Age range: 1 Year to 17 Years

🧪 Interventions in This Study

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (32 Sites)

Showing the first 25 of 32 sites.

  • Investigational Site Number : 0320004 — San Miguel de Tucumán, Tucumán Province
  • Investigational Site Number : 0320005 — Buenos Aires,
  • Investigational Site Number : 1240110 — Calgary, Alberta
  • Investigational Site Number : 2460040 — Helsinki,
  • Investigational Site Number : 2500041 — Bron,
  • Investigational Site Number : 2500042 — Montpellier,
  • Investigational Site Number : 2500040 — Paris,
  • Investigational Site Number : 2760064 — Berlin,
  • Investigational Site Number : 2760065 — Berlin,
  • Investigational Site Number : 2760062 — Hamburg,
  • Investigational Site Number : 2760060 — Sankt Augustin,
  • Investigational Site Number : 2760063 — Sendenhorst,
  • Investigational Site Number : 3000001 — Athens,
  • Investigational Site Number : 3000002 — Thessaloniki,
  • Investigational Site Number : 3720001 — Crumlin, Dublin
  • Investigational Site Number : 3800051 — Genoa, Genova
  • Investigational Site Number : 3800054 — Milan, Milano
  • Investigational Site Number : 3800052 — Rome, Roma
  • Investigational Site Number : 6200003 — Lisbon,
  • Investigational Site Number : 6430001 — Moscow,
  • Investigational Site Number : 6430062 — Moscow,
  • Investigational Site Number : 6430063 — Moscow,
  • Investigational Site Number : 6430065 — Ufa,
  • Investigational Site Number : 7240055 — Barcelona, Barcelona [Barcelona]
  • Investigational Site Number : 7240050 — Esplugues de Llobregat, Barcelona [Barcelona]

📞 Contact the Study Coordinator

Phone: (800) 633-1610

Email: Contact-Us@sanofi.com

Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Contact the study coordinator using the phone/email above.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗