๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-01-08

A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants With Ulcerative Colitis (UC) (NCT03006068)

A Phase 3 Multicenter, Long-Term Extension Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) in Subjects With Ulcerative Colitis

๐Ÿ”ต Active, Not Recruiting Phase3 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: AbbVie

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This study is designed to evaluate the long-term safety and efficacy of Upadacitinib in participants with ulcerative colitis (UC) who have not responded at the end of the induction period in Study M14-234 Substudy 1, who have had loss of response during the maintenance period of Study M14-234 Substudy 3, or who have successfully completed Study M14-234 Substudy 3.

Who can join: Review the eligibility criteria below.

Location: East View Medical Research, LLC /ID# 171184 โ€” Mobile, Alabama

Age range: 16 Years to 75 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (492 Sites)

Showing the first 25 of 492 sites.

  • East View Medical Research, LLC /ID# 171184 โ€” Mobile, Alabama
  • CB Flock Research Corporation /ID# 165986 โ€” Mobile, Alabama
  • Delsol Research Management, Ll /Id# 170130 โ€” Chandler, Arizona
  • Digestive Disease Consultants, A Division of Arizona Digestive Health, P.C /ID# 211886 โ€” Mesa, Arizona
  • Duplicate_Arizona Arthritis & Rheumatology Research, PLLC /ID# 169823 โ€” Sun City, Arizona
  • Adobe Clinical Research LLC /ID# 155249 โ€” Tucson, Arizona
  • Duplicate_University of Arizona /ID# 150568 โ€” Tucson, Arizona
  • Citrus Valley Gastroenterology /ID# 151915 โ€” Covina, California
  • Newport Huntington Medical Group /ID# 217006 โ€” Huntington Beach, California
  • UC San Diego Health System /ID# 155187 โ€” La Jolla, California
  • United Medical Doctors /ID# 207467 โ€” Los Alamitos, California
  • TLC Clinical Research Inc /ID# 216830 โ€” Los Angeles, California
  • Gastrointestinal Biosciences Clinical Trials, LLC /ID# 157082 โ€” Los Angeles, California
  • Facey Medical Foundation /ID# 203135 โ€” Mission Hills, California
  • United Medical Doctors - Murrieta /ID# 151213 โ€” Murrieta, California
  • Ventura County Gastroenterology Medical Group /ID# 163417 โ€” Oxnard, California
  • Inland Empire Clinical Trials, LLC /ID# 216163 โ€” Rialto, California
  • San Diego Clinical Trials /ID# 212121 โ€” San Diego, California
  • Medical Assoc Research Grp /ID# 169149 โ€” San Diego, California
  • Univ of California San Francis /ID# 164583 โ€” San Francisco, California
  • Delta Waves, Inc. /ID# 151727 โ€” Colorado Springs, Colorado
  • South Denver Gastroenterology /ID# 151224 โ€” Lone Tree, Colorado
  • Western States Clinical Res /ID# 158078 โ€” Wheat Ridge, Colorado
  • Duplicate_Western Connecticut Medical Group /ID# 169211 โ€” Danbury, Connecticut
  • Gastroenterology Center of Connecticut /ID# 150534 โ€” Hamden, Connecticut

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—