Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer (NCT03155997)
A Randomized, Open-Label, Phase 3 Study of Abemaciclib Combined With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone in Patients With High Risk, Node Positive, Early Stage, Hormone Receptor Positive, Human Epidermal Receptor 2 Negative, Breast Cancer
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to evaluate the safety and efficacy of the study drug abemaciclib in participants with high risk, node positive, early stage, hormone receptor positive (HR+), human epidermal receptor 2 negative (HER2-), breast cancer.
Who can join: Review the eligibility criteria below.
Location: University of Alabama Birmingham — Birmingham, Alabama
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (619 Sites)
Showing the first 25 of 619 sites.
- University of Alabama Birmingham — Birmingham, Alabama
- Providence Alaska Medical Center — Anchorage, Alaska
- Banner MD Anderson Cancer Center — Gilbert, Arizona
- Arizona Oncology Associates, P.C. - HOPE — Goodyear, Arizona
- St. Joseph's Hospital and Medical Center — Phoenix, Arizona
- Mayo Clinic Hospital — Phoenix, Arizona
- The University of Arizona Cancer Center — Tucson, Arizona
- Yuma Regional Cancer Center — Yuma, Arizona
- St. Bernards Medical Center — Jonesboro, Arkansas
- Highlands Oncology Group — Springdale, Arkansas
- Beverly Hills Cancer Center — Beverly Hills, California
- Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center — Burbank, California
- City of Hope National Medical Center — Duarte, California
- California Cancer Associates Research and Excellence — Fresno, California
- Kaiser Permanente — Harbor City, California
- Loma Linda University School of Medicine — Loma Linda, California
- Cedars-Sinai Medical Center — Los Angeles, California
- Pacific Cancer Care — Monterey, California
- St. Joseph Hospital — Orange, California
- University of California Davis (UC Davis) Comprehensive Cancer Center — Sacramento, California
- UCSF Medical Center at Mission Bay — San Francisco, California
- California Cancer Associates in Research and Excellence — San Marcos, California
- Dignity Health Dominican Oncology and Hematology — Santa Cruz, California
- Kaiser Permanente — Vallejo, California
- USO-Rocky Mountain Cancer Center — Boulder, Colorado
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- [177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer — Los Angeles, California
- Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery — Durham, North Carolina
- TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study B) — Palo Alto, California
- A Multi Modality Surveillance Program for Women At High Risk for Breast Cancer — Chicago, Illinois
- ATOP TRIAL: T-DM1 in HER2 Positive Breast Cancer — Duarte, California
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.