🏛️ Verified NIH Record • Updated 2026-06-22

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery (NCT03180268)

Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma

🟢 Recruiting Phase3 🩺 Clinical Procedure Protocol Sponsor: NRG Oncology

🩺 Plain-English Summary (8th-Grade Level)

This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.

Who can join: Review the eligibility criteria below.

Location: University of Alabama at Birmingham Cancer Center — Birmingham, Alabama

Age range: 18 Years

🧪 Interventions in This Study

  • Biospecimen Collection (PROCEDURE)
  • Clinical Observation (OTHER)
  • Intensity-Modulated Radiation Therapy (RADIATION)
  • Laboratory Biomarker Analysis (OTHER)
  • Magnetic Resonance Imaging (PROCEDURE)
  • Proton Beam Radiation Therapy (RADIATION)
  • Quality-of-Life Assessment (OTHER)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (215 Sites)

Showing the first 25 of 215 sites.

  • University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
  • Saint Joseph's Hospital and Medical Center — Phoenix, Arizona
  • Mayo Clinic Hospital in Arizona — Phoenix, Arizona
  • Mayo Clinic in Arizona — Scottsdale, Arizona
  • University of Arizona Cancer Center-Orange Grove Campus — Tucson, Arizona
  • Banner University Medical Center - Tucson — Tucson, Arizona
  • University of Arizona Cancer Center-North Campus — Tucson, Arizona
  • Kaiser Permanente-Anaheim — Anaheim, California
  • Sutter Cancer Centers Radiation Oncology Services-Auburn — Auburn, California
  • Kaiser Permanente-Bellflower — Bellflower, California
  • Kaiser Permanente Dublin — Dublin, California
  • Kaiser Permanente Los Angeles Medical Center — Los Angeles, California
  • Los Angeles General Medical Center — Los Angeles, California
  • USC / Norris Comprehensive Cancer Center — Los Angeles, California
  • Memorial Medical Center — Modesto, California
  • Kaiser Permanente Oakland-Broadway — Oakland, California
  • Kaiser Permanente-Ontario — Ontario, California
  • UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California
  • Stanford Cancer Institute Palo Alto — Palo Alto, California
  • Kaiser Permanente-Rancho Cordova Cancer Center — Rancho Cordova, California
  • Rohnert Park Cancer Center — Rohnert Park, California
  • Sutter Cancer Centers Radiation Oncology Services-Roseville — Roseville, California
  • The Permanente Medical Group-Roseville Radiation Oncology — Roseville, California
  • Sutter Medical Center Sacramento — Sacramento, California
  • South Sacramento Cancer Center — Sacramento, California

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

More studies in Grade 2 Meningioma

Explore by condition: All Grade 2 Meningioma clinical trials

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗