๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-08-01

Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change (NCT03191149)

Phase II Study of Osimertinib (AZD9291) in Advanced NSCLC Patients With Exon 20 Insertion Mutations in EGFR

๐ŸŸข Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: National Cancer Institute (NCI)

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This phase II trial studies how well osimertinib works in treating patients with non-small cell lung cancer with EGFR exon 20 insertion mutation that is stage IIIB-IV or has come back after a period of improvement (recurrent). Osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Who can join: Review the eligibility criteria below.

Location: Anchorage Associates in Radiation Medicine โ€” Anchorage, Alaska

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (344 Sites)

Showing the first 25 of 344 sites.

  • Anchorage Associates in Radiation Medicine โ€” Anchorage, Alaska
  • Anchorage Radiation Therapy Center โ€” Anchorage, Alaska
  • Alaska Breast Care and Surgery LLC โ€” Anchorage, Alaska
  • Alaska Oncology and Hematology LLC โ€” Anchorage, Alaska
  • Alaska Women's Cancer Care โ€” Anchorage, Alaska
  • Anchorage Oncology Centre โ€” Anchorage, Alaska
  • Katmai Oncology Group โ€” Anchorage, Alaska
  • Providence Alaska Medical Center โ€” Anchorage, Alaska
  • Fairbanks Memorial Hospital โ€” Fairbanks, Alaska
  • Mercy Hospital Fort Smith โ€” Fort Smith, Arkansas
  • CARTI Cancer Center โ€” Little Rock, Arkansas
  • Providence Saint Joseph Medical Center/Disney Family Cancer Center โ€” Burbank, California
  • MedStar Georgetown University Hospital โ€” Washington D.C., District of Columbia
  • Holy Cross Hospital โ€” Fort Lauderdale, Florida
  • Emory University Hospital Midtown โ€” Atlanta, Georgia
  • Emory University Hospital/Winship Cancer Institute โ€” Atlanta, Georgia
  • Emory Saint Joseph's Hospital โ€” Atlanta, Georgia
  • Saint Alphonsus Cancer Care Center-Boise โ€” Boise, Idaho
  • Saint Luke's Cancer Institute - Boise โ€” Boise, Idaho
  • Saint Alphonsus Cancer Care Center-Caldwell โ€” Caldwell, Idaho
  • Kootenai Health - Coeur d'Alene โ€” Coeur d'Alene, Idaho
  • Walter Knox Memorial Hospital โ€” Emmett, Idaho
  • Saint Luke's Cancer Institute - Fruitland โ€” Fruitland, Idaho
  • Idaho Urologic Institute-Meridian โ€” Meridian, Idaho
  • Saint Luke's Cancer Institute - Meridian โ€” Meridian, Idaho

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—