Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma (NCT03228537)
A Feasibility Trial of Neoadjuvant Cisplatin-Pemetrexed With Atezolizumab in Combination and in Maintenance for Resectable Malignant Pleural Mesothelioma
🩺 Plain-English Summary (8th-Grade Level)
This phase I pilot trial studies how well atezolizumab, pemetrexed disodium, cisplatin, and surgery with or without radiation therapy works in treating patients with stage I-III pleural malignant mesothelioma. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Pemetrexed disodium may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving atezolizumab, pemetrexed disodium, and cisplatin before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving atezolizumab after surgery may kill any remaining tumor cells.
Who can join: Review the eligibility criteria below.
Location: Mayo Clinic Hospital in Arizona — Phoenix, Arizona
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (174 Sites)
Showing the first 25 of 174 sites.
- Mayo Clinic Hospital in Arizona — Phoenix, Arizona
- Mayo Clinic in Arizona — Scottsdale, Arizona
- CHI Saint Vincent Cancer Center Hot Springs — Hot Springs, Arkansas
- PCR Oncology — Arroyo Grande, California
- City of Hope Comprehensive Cancer Center — Duarte, California
- University of California Davis Comprehensive Cancer Center — Sacramento, California
- Penrose-Saint Francis Healthcare — Colorado Springs, Colorado
- Rocky Mountain Cancer Centers-Penrose — Colorado Springs, Colorado
- AdventHealth Porter — Denver, Colorado
- CommonSpirit Cancer Center Mercy — Durango, Colorado
- Mercy Medical Center — Durango, Colorado
- Mountain Blue Cancer Care Center — Golden, Colorado
- CommonSpirit Saint Anthony Hospital Cancer Center — Lakewood, Colorado
- Rocky Mountain Cancer Centers-Lakewood — Lakewood, Colorado
- AdventHealth Littleton — Littleton, Colorado
- Longmont United Hospital — Longmont, Colorado
- Rocky Mountain Cancer Centers-Longmont — Longmont, Colorado
- AdventHealth Parker — Parker, Colorado
- Rocky Mountain Cancer Centers-Parker — Parker, Colorado
- Saint Mary Corwin Medical Center — Pueblo, Colorado
- Rocky Mountain Cancer Centers - Pueblo — Pueblo, Colorado
- Rocky Mountain Cancer Centers-Thornton — Thornton, Colorado
- Baptist MD Anderson Cancer Center — Jacksonville, Florida
- Saint Alphonsus Cancer Care Center-Boise — Boise, Idaho
- Saint Alphonsus Cancer Care Center-Caldwell — Caldwell, Idaho
📞 Contact the Study Coordinator
Phone: (800) 664-4580
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Biphasic Mesothelioma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.