๐Ÿ›๏ธ Verified NIH Record โ€ข Updated 2026-07-30

Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2 (NCT03284385)

A Phase 2 Study of AZD1775 in SETD2-Deficient Advanced Solid Tumor Malignancies

๐Ÿ”ต Active, Not Recruiting Phase2 ๐Ÿ’Š Investigational Drug / Biologic Sponsor: National Cancer Institute (NCI)

๐Ÿฉบ Plain-English Summary (8th-Grade Level)

This phase II trial studies how well adavosertib works in treating patients with SETD2-deficient solid tumors that have spread to other places in the body (advanced/metastatic). Adavosertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Who can join: Review the eligibility criteria below.

Location: UC Irvine Health/Chao Family Comprehensive Cancer Center โ€” Orange, California

Age range: 18 Years

๐Ÿงช Interventions in This Study

๐Ÿ“‹ "Do I Qualify?" โ€” 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria โ†—

๐Ÿ“ All Participating Trial Locations (29 Sites)

Showing the first 25 of 29 sites.

  • UC Irvine Health/Chao Family Comprehensive Cancer Center โ€” Orange, California
  • University of California Davis Comprehensive Cancer Center โ€” Sacramento, California
  • UCSF Medical Center-Mount Zion โ€” San Francisco, California
  • UCSF Medical Center-Mission Bay โ€” San Francisco, California
  • MedStar Georgetown University Hospital โ€” Washington D.C., District of Columbia
  • Northwestern University โ€” Chicago, Illinois
  • University of Chicago Comprehensive Cancer Center โ€” Chicago, Illinois
  • UC Comprehensive Cancer Center at Silver Cross โ€” New Lenox, Illinois
  • University of Chicago Medicine-Orland Park โ€” Orland Park, Illinois
  • University of Kansas Clinical Research Center โ€” Fairway, Kansas
  • University of Kansas Cancer Center โ€” Kansas City, Kansas
  • University of Kansas Hospital-Westwood Cancer Center โ€” Westwood, Kansas
  • Johns Hopkins University/Sidney Kimmel Cancer Center โ€” Baltimore, Maryland
  • Massachusetts General Hospital Cancer Center โ€” Boston, Massachusetts
  • Brigham and Women's Hospital โ€” Boston, Massachusetts
  • Beth Israel Deaconess Medical Center โ€” Boston, Massachusetts
  • Dana-Farber Cancer Institute โ€” Boston, Massachusetts
  • Wayne State University/Karmanos Cancer Institute โ€” Detroit, Michigan
  • Weisberg Cancer Treatment Center โ€” Farmington Hills, Michigan
  • Siteman Cancer Center at Saint Peters Hospital โ€” City of Saint Peters, Missouri
  • Siteman Cancer Center at West County Hospital โ€” Creve Coeur, Missouri
  • Washington University School of Medicine โ€” St Louis, Missouri
  • Siteman Cancer Center-South County โ€” St Louis, Missouri
  • Siteman Cancer Center at Christian Hospital โ€” St Louis, Missouri
  • Laura and Isaac Perlmutter Cancer Center at NYU Langone โ€” New York, New York

๐Ÿ’ฐ Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

๐Ÿ’ก How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
๐Ÿ›๏ธ View Official NIH Record โ†—