Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer (NCT03422198)
Short Course Adjuvant Vaginal Cuff Brachytherapy (VCB) in Early Endometrial Cancer Compared to Standard of Care (SAVE)
🩺 Plain-English Summary (8th-Grade Level)
This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating participants with stage I-II endometrial cancer. Short course vaginal cuff brachytherapy, also known as internal radiation therapy, uses (over a shorter period) radioactive material placed directly into or near a tumor in the upper portion of the vagina to kill tumor cells. After completion of cohort 1 (108 participants), the protocol was expended to add a second cohort of 80 additional participants, and re-opened study recruitment.
Who can join: Review the eligibility criteria below.
Location: Stanford Cancer Center — Palo Alto, California
🧪 Interventions in This Study
- Vaginal Cuff Brachytherapy (RADIATION)
- Short course vaginal cuff brachytherapy (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (5 Sites)
- Stanford Cancer Center — Palo Alto, California
- Loyola University Medical Center — Maywood, Illinois
- MD Anderson — Houston, Texas
- Huntsman Cancer Institute/University of Utah — Salt Lake City, Utah
- Intermountain Medical Center / LDS Hospital — Salt Lake City, Utah
📞 Contact the Study Coordinator
Phone: (801) 585-0115
Email: Rachel.Kingsford@hci.utah.edu
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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- Testing the Addition of the Immunotherapy Drug Pembrolizumab to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) in Stage III-IV or Recurrent Endometrial Cancer — Birmingham, Alabama
- Determine the Utility of Liquid Biopsies and Tumor Molecular Profiling in Predicting Recurrence in Endometrial Cancers — Houston, Texas
Explore by condition: All Endometrial Clear Cell Adenocarcinoma clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.