🏛️ Verified NIH Record • Updated 2026-04-20
Management of the PDA Trial (NCT03456336)
Management of the Patent Ductus Arteriosus in Premature Infants Trial (PDA Trial)
🔵 Active, Not Recruiting Phase3 📋 Clinical Research Protocol Sponsor: NICHD Neonatal Research Network
🩺 Plain-English Summary (8th-Grade Level)
Estimate the risks and benefits of active treatment versus expectant management of a symptomatic patent ductus arteriosus (sPDA) in premature infants.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham — Birmingham, Alabama
Age range: 48 Hours to 21 Days
🧪 Interventions in This Study
- Active Treatment (OTHER)
- Expectant Management (OTHER)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (19 Sites)
- University of Alabama at Birmingham — Birmingham, Alabama
- Stanford University — Palo Alto, California
- Sharp Mary Birch Hospital for Women & Newborns — San Diego, California
- Emory University — Atlanta, Georgia
- Northwestern Lurie Children's Hospital of Chicago — Chicago, Illinois
- University of Iowa — Iowa City, Iowa
- University of Mississippi Medical Center - Children's of Mississippi — Jackson, Mississippi
- University of New Mexico — Albuquerque, New Mexico
- University of Rochester — Rochester, New York
- RTI International — Durham, North Carolina
- Duke University — Durham, North Carolina
- Cincinnati Children's Medical Center — Cincinnati, Ohio
- Case Western Reserve University, Rainbow Babies and Children's Hospital — Cleveland, Ohio
- Research Institute at Nationwide Children's Hospital — Columbus, Ohio
- University of Pennsylvania — Philadelphia, Pennsylvania
- Brown University - Women and Infants Hospital of Rhode Island — Providence, Rhode Island
- University of Texas Southwestern Medical Center at Dallas — Dallas, Texas
- University of Texas Health Science Center at Houston — Houston, Texas
- University of Utah — Salt Lake City, Utah
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
Explore by condition: All Infant, Premature clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.