Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS) (NCT03513614)
Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS). A Multicenter Randomized Phase III Trial (OPBC-03/ SAKK 23/16 /IBCSG 57-18 / ABCSG-53 / GBG-101)
🩺 Plain-English Summary (8th-Grade Level)
RATIONALE: The use of tailored axillary dissection as a tailored procedure will avoid surgical overtreatment by selectively removing the lymph nodes that are affected by the cancer, thereby sparing many women the unnecessary complications of a radical surgery, providing a better quality of life while keeping the same efficacy. PURPOSE: The phase III trial is evaluating the optimal treatment for breast cancer patients in terms of surgery and radiotherapy.
Who can join: Review the eligibility criteria below.
Location: Walter Reed National Military Medical Center — Bethesda, Maryland
Age range: 18 Years
🧪 Interventions in This Study
- Tailored axillary surgery - both Arms (PROCEDURE)
- Radiotherapy - Arm A (RADIATION)
- Radiotherapy - Arm B (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (64 Sites)
Showing the first 25 of 64 sites.
- Walter Reed National Military Medical Center — Bethesda, Maryland
- Duke University/Duke Cancer Center — Durham, North Carolina
- Swedish Cancer Institute — Seattle, Washington
- Sanatorio Parque Breast Cancer Center — Rosario, Santa Fe Province
- Institute of Oncology "Angel H. Roffo — Buenos Aires,
- Krankenhaus Dornbirn — Dornbirn,
- Landeskrankenhaus Feldkirch — Feldkirch,
- Medical University of Innsbruck, Department of Gynecology — Innsbruck,
- Ordens Kinikum Linz, Barmherzige Schwestern — Linz,
- Universitätsklinik für Frauenheilkunde und Geburtshilfe; Landeskrankenhaus Salzburg der PMU — Salzburg,
- Medizinische Universität Wien - Klinik für Chirurgie — Vienna,
- Medizinische Universität Wien - Universitätsklinik für Frauenheilkunde — Vienna,
- Hanusch Hospital Vienna — Vienna,
- Klinikum Wels-Grieskrichen GmbH — Wels,
- CIUSSS du Centre Ouest-de-l'Île-de-Montréal, Jewish General Hospital — Montreal,
- Breast Centre of Clinical Hospital — Rijeka,
- HRUHC Sestre milosdrnice — Zagreb,
- KEM | Evang. Kliniken Essen-Mitte gGmbH — Essen,
- Niels-Stensen-Kliniken Franziskus-Hospital Harderberg — Georgsmarienhütte,
- Universitätsklinikum Heidelberg, Sektion Senologie — Heidelberg,
- ViDia Christliche Kliniken Karlsruhe, Diakonissenkrankenhaus — Karlsruhe,
- Helios University Hospital Wuppertal — Wuppertal,
- Attikon University Hospital — Chaïdári, Athens
- University Hospital of Heraklion — Heraklion, Crete
- Alexandra General Hospital — Athens,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Node-positive Breast Cancer
Explore by condition: All Node-positive Breast Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.