🏛️ Verified NIH Record • Updated 2026-05-25
RNA Disruption Assay (RDA)-Breast Cancer Response Evaluation for Individualized Therapy (NCT03524430)
RNA Disruption Assay (RDA)-Breast Cancer Response Evaluation for Individualized Therapy (BREVITY / BREVITY-02 in Germany)
🔵 Active, Not Recruiting Observational / Diagnostic 🩺 Clinical Procedure Protocol Sponsor: Rna Diagnostics Inc.
🩺 Plain-English Summary (8th-Grade Level)
The current study aims to provide validation results of RNA Disruption Assay (RDA) as a tumour response assessment tool that uses tumour core biopsies taken starting from 35 +/- 4 days after the initiation of neoadjuvant chemotherapy.
Who can join: Review the eligibility criteria below.
Location: Siteman Cancer Center — St Louis, Missouri
Age range: 18 Years
🧪 Interventions in This Study
- Core needle biopsy (PROCEDURE)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (7 Sites)
- Siteman Cancer Center — St Louis, Missouri
- Sunnybrook Health Sciences Center — Toronto,
- Institut de Cancerologie de Strasbourg — Strasbourg,
- Universitätsklinikum Münster — Münster,
- SST di Cremona Multidisciplinare di Patologia Mammaria, Italy — Cremona,
- NZOZ Neuromed — Lublin,
- Hospital U. 12 de Octubre — Madrid,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
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💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.