🏛️ Verified NIH Record • Updated 2026-05-25

RNA Disruption Assay (RDA)-Breast Cancer Response Evaluation for Individualized Therapy (NCT03524430)

RNA Disruption Assay (RDA)-Breast Cancer Response Evaluation for Individualized Therapy (BREVITY / BREVITY-02 in Germany)

🔵 Active, Not Recruiting Observational / Diagnostic 🩺 Clinical Procedure Protocol Sponsor: Rna Diagnostics Inc.

🩺 Plain-English Summary (8th-Grade Level)

The current study aims to provide validation results of RNA Disruption Assay (RDA) as a tumour response assessment tool that uses tumour core biopsies taken starting from 35 +/- 4 days after the initiation of neoadjuvant chemotherapy.

Who can join: Review the eligibility criteria below.

Location: Siteman Cancer Center — St Louis, Missouri

Age range: 18 Years

🧪 Interventions in This Study

  • Core needle biopsy (PROCEDURE)

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (7 Sites)

  • Siteman Cancer Center — St Louis, Missouri
  • Sunnybrook Health Sciences Center — Toronto,
  • Institut de Cancerologie de Strasbourg — Strasbourg,
  • Universitätsklinikum Münster — Münster,
  • SST di Cremona Multidisciplinare di Patologia Mammaria, Italy — Cremona,
  • NZOZ Neuromed — Lublin,
  • Hospital U. 12 de Octubre — Madrid,

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

💡 How to Participate

  1. Check the checklist above to see if you may qualify.
  2. Review the official NIH record below to find the coordinating site.
  3. Ask about the visit schedule, what is covered at no cost, and any travel support.
  4. Confirm with your own doctor before making a decision.
🏛️ View Official NIH Record ↗