🏛️ Verified NIH Record • Updated 2026-03-05
A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer (NCT03561220)
🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol Sponsor: University of Florida
🩺 Plain-English Summary (8th-Grade Level)
This study is a large, prospective, pragmatic, controlled comparison of patient-centric outcomes \[quality of life (QOL), toxicity, and disease control\] between parallel cohorts of men with prostate cancer treated simultaneously at proton therapy facilities and at geographically similar conventional (photon-based) radiation facilities using intensity-modulated radiation therapy (IMRT) techniques.
Who can join: Review the eligibility criteria below.
Location: University of Alabama at Birmingham (UAB) — Birmingham, Alabama
Age range: 30 Years to 85 Years
🧪 Interventions in This Study
- Standard of Care IMRT (Photon) (RADIATION)
- Standard of Care Proton Therapy (RADIATION)
- Proton Arm 1: Standard Proton Therapy (RADIATION)
- Proton Arm 2: Hypofractionated Proton Therapy (RADIATION)
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (53 Sites)
Showing the first 25 of 53 sites.
- University of Alabama at Birmingham (UAB) — Birmingham, Alabama
- University of California San Diego — La Jolla, California
- Proton Therapy Treatment Center - Loma Linda University — Loma Linda, California
- Sutter Health — Roseville, California
- California Protons Cancer Therapy Center — San Diego, California
- Department of Radiation Oncology Davis Cancer Pavilion — Gainesville, Florida
- University of Florida Proton Therapy Institute — Jacksonville, Florida
- Ackerman Cancer Center — Jacksonville, Florida
- Mayo Clinic — Jacksonville, Florida
- University of Miami School of Medicine — Miami, Florida
- Miami Cancer Institute — Miami, Florida
- Orlando Health UF Health Center — Orlando, Florida
- Winship Cancer Institute - Emory University — Atlanta, Georgia
- University of Chicago — Chicago, Illinois
- Northwestern Medicine Proton Center — Warrenville, Illinois
- University of Kansas Medical Center — Lawrence, Kansas
- University of Louisville — Louisville, Kentucky
- Willis-Knighton Medical Center PTC — Shreveport, Louisiana
- Johns Hopkins University — Baltimore, Maryland
- University of Maryland — College Park, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- Karmanos Cancer Institute — Detroit, Michigan
- Mayo Clinic Health System — Mankato, Minnesota
- Mayo Clinic — Rochester, Minnesota
- S Lee Kling Proton Therapy Center - Washington University Medical Center — St Louis, Missouri
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Prostate Cancer
- A Study of Apalutamide (JNJ-56021927, ARN-509) Plus Androgen Deprivation Therapy (ADT) Versus ADT in Participants With mHSPC — Homewood, Alabama
- A Study in Which Non-metastatic Castration-resistant Prostate Cancer (nmCRPC) Patients for Whom a Decision to Treat With Darolutamide Has Been Made Before Enrollment Are Observed and Certain Outcomes Are Described — Homewood, Alabama
- Stereotactic Ablative Radiation Therapy for Prostate Cancer — Charleston, South Carolina
- A Study of Stereotactic Body Radiation Therapy (SBRT) Without Androgen Deprivation Therapy (ADT) in People With Unfavorable Intermediate-Risk Prostate Cancer — Basking Ridge, New Jersey
- A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer — Phoenix, Arizona
- Neoadjuvant Enoblituzumab (MGA271) in Men With Localized Intermediate and High-Risk Prostate Cancer — Baltimore, Maryland
Explore by condition: All Prostate Cancer clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Review the official NIH record below to find the coordinating site.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.