Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE) (NCT03573089)
An Investigator-initiated, International, Multi-centre, Prospective, Randomized, Open-label, Parallel-group, Superiority, and Pragmatic Large Simple Trial (LST) to Determine Whether the Currently Recommended Strategy of Intensive Reduction of Serum Phosphate Concentration Towards the Normal Level Results in Significant Patient-centred Benefits in End-stage Kidney Disease (ESKD) Patients Receiving Dialysis.
🩺 Plain-English Summary (8th-Grade Level)
During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.
Who can join: Review the eligibility criteria below.
Location: Royal Prince Alfred Hosptial — Camperdown, New South Wales
Age range: 18 Years
🧪 Interventions in This Study
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (126 Sites)
Showing the first 25 of 126 sites.
- Royal Prince Alfred Hosptial — Camperdown, New South Wales
- Nepean Hospital — Kingswood, New South Wales
- St George Hospital — Kogarah, New South Wales
- Royal North Shore Hospital — Saint Leonards, New South Wales
- Western Sydney Renal Service — Westmead, New South Wales
- Wollongong Hospital — Wollongong, New South Wales
- Sunshine Coast University Hospital — Birtinya, Queensland
- Royal Brisbane and Women's Hospital — Brisbane, Queensland
- Princess Alexandra Hospital — Brisbane, Queensland
- Bundaberg Hospital — Bundaberg, Queensland
- Cairns Hospital — Cairns, Queensland
- Fraser Coast Renal Service — Hervey Bay, Queensland
- Mackay Hospital — Mackay, Queensland
- Logan Hospital — Meadowbrook, Queensland
- Gold Coast University Hospital — Southport, Queensland
- Townsville University Hospital — Townsville, Queensland
- Central and Northern Adelaide Renal and Transplant Service — Adelaide, South Australia
- Flinders Medical Centre — Bedford Park, South Australia
- Austin Health — Heidelberg, Victoria
- Royal Melbourne Hospital — Melbourne, Victoria
- St Vincent's Hospital Melbourne — Melbourne, Victoria
- Latrobe Regional Hospital — Traralgon, Victoria
- Armadale Hospital — Armadale, Washington
- Serviço Ubaense de Nefrologia Ltda — Ubá, Minas Gerais
- BRA Santa Casa de Misericórdia de Ponta Grossa — Ponta Grossa, Paraná
📞 Contact the Study Coordinator
Phone: (416) 867-3703
Email: WaldR@smh.ca
Coordinator details come directly from the registered NIH protocol. Confirm the study is still recruiting before traveling.
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
More studies in Kidney Failure, Chronic
- Empagliflozin in ESKD - A Feasibility Study — Jackson, Mississippi
- Clazakizumab in Highly-HLA Sensitized Patients Awaiting Renal Transplant — Los Angeles, California
- DePTH: De-emphasize PTH — Seattle, Washington
- A Study to Evaluate the Pharmacokinetics and Safety of Golcadomide in Participants With Severe Renal Impairment and End-Stage Renal Disease Compared With Participants With Normal Renal Function — Chandler, Arizona
- International (Pediatric) Peritoneal Biobank — Birmingham, Alabama
Explore by condition: All Kidney Failure, Chronic clinical trials
💡 How to Participate
- Check the checklist above to see if you may qualify.
- Contact the study coordinator using the phone/email above.
- Ask about the visit schedule, what is covered at no cost, and any travel support.
- Confirm with your own doctor before making a decision.